Aprepitant Impurity 15 CAS 1447693-83-5
| CAS No. | 1447693-83-5 |
| Molecular Formula | C20H18F7NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Aprepitant Impurity 15 (CAS 1447693-83-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18F7NO2HCl and a molecular weight of 473.81 g/mol.
Structurally, Aprepitant Impurity 15 (C20H18F7NO2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 473.81 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Aprepitant Impurity 15 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H18F7NO2 HCl |
| Molecular Weight | 473.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Phenylephrine impurity 94 (CAS 83070-12-6)
- Sacubitril impurity 14 (CAS 219799-66-3（free base）)
- Pentoxifylline Impurity 9 (CAS 1597448-45-7)
- 1-(2,3-dichlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde (CAS 1423029-67-7)
- (5S,8s)-2-azaspiro[4.5]Decan-8-ol (CAS 1932267-88-3)
- N-(4-bromobenzyl)thietan-3-amine (CAS 1784020-27-4)
- 3-Chloro-2-(pyrrolidin-3-ylmethoxy)-5-(trifluoromethyl)pyridine hydrochloride (CAS 1417794-08-1)
- N-[(4-Chlorophenyl)methyl]-2-oxo-1-{[4-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 338782-35-7)
- tert-Butyl N-({[3-(propan-2-yl)phenyl]carbamoyl}methyl)carbamate (CAS 1390344-75-8)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
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