Cabozantinib Impurity 47 CAS CATO-C4X-201847
| CAS No. | CATO-C4X-201847 |
| Molecular Formula | C28H23FN4O6 |
| Molecular Weight | 530.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Cabozantinib Impurity 47 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Cabozantinib Impurity 47 (CAS CATO-C4X-201847, C28H23FN4O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H23FN4O6, Cabozantinib Impurity 47 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 530.50 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C28H23FN4O6 |
| Molecular Weight | 530.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ＞95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Cabozantinib Standards
- Cabozantinib Impurity N1 (CAS 1628530-38-0)
- Cabozantinib Impurity 36 (CAS 1628530-41-5)
- Cabozantinib N-oxide (CAS 1621681-63-7)
- Cabozantinib-d6 (CAS 1802168-46-2)
- Cabozantinib-d4 (CAS 1802168-53-1)
- Cabozantinib (CAS 849217-68-1)
- Cabozantinib Impurity 17 (CAS CATO-C4X-201817)
- Cabozantinib Impurity 34 (CAS CATO-C4X-201834)
Recommended Standards
- Radotinib (CAS 926037-48-1)
- 3-{2-[3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazol-4-yl}-4-(prop-2-en-1-yl)-5-({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)-4H-1,2,4-triazole (CAS 956755-10-5)
- Lenalidomide Impurity 40 (CAS CATO-C4X-190340)
- 1,3-Dimethyl 5,5-dicyano-2-hydroxy-6-[4-(methylsulfanyl)phenyl]-4-[4-(trifluoromethyl)phenyl]cyclohex-1-ene-1,3-dicarboxylate (CAS 1212184-75-2)
- Olaparib Impurity 25 Acetate (CAS 143238-38-4)
- Buspirone EP Impurity E (CAS 257877-43-3)
- Rosuvastatin Impurity 167 (CAS CATO-C4X-1169167)
- (E)-[(4-Methylphenyl)methoxy]({2-[(4-methylphenyl)sulfanyl]pyridin-3-yl}methylidene)amine (CAS 477885-93-1)
- 2-(4-Butoxyphenyl)-4-methylpyrrolidine (CAS 603089-63-0)
- 2-(Thiophen-2-yl)cyclopentan-1-ol (CAS 115754-92-2)
- 1-(3-Bromophenyl)-N-(2-ethoxyethyl)ethan-1-amine (CAS 1156244-65-3)
- 4-Chloro-2-((1,3-dihydroxypropan-2-yl)amino)benzonitrile (CAS 1384807-05-9)
- 2-((6-(Adamantan-1-yl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl)thio)-2-phenylacetic acid (CAS 488827-01-6)
- Stresscopin-Related Peptide (human) (CAS 348626-74-4)
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