Cabozantinib Impurity 53 CAS CATO-C4X-201853
| CAS No. | CATO-C4X-201853 |
| Molecular Formula | C56H49F2N6O10 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cabozantinib Impurity 53.
Cabozantinib Impurity 53 (CAS CATO-C4X-201853) is a certified pharmaceutical impurity reference standard with the molecular formula C56H49F2N6O10Br and a molecular weight of 1083.94 g/mol.
The molecular framework of Cabozantinib Impurity 53 (C56H49F2N6O10Br) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Cabozantinib Impurity 53 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C56H49F2N6O10 Br |
| Molecular Weight | 1083.94 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 34.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 6 |
Related Cabozantinib Standards
- Cabozantinib Impurity N2 (CAS 113136-79-1)
- Cabozantinib Malate (CAS 1140909-48-3)
- Cabozantinib Impurity 4 (CAS 1247859-37-5)
- Cabozantinib Impurity 40 (CAS 1275738-77-6)
- Cabozantinib 4-Fluorocarbamoyl Methyl Ester Impurity (CAS 1345847-71-3)
- Cabozantinib Impurity 3 (CAS 1431468-36-8)
- Cabozantinib Impurity 12 (CAS 145591-80-6)
- Cabozantinib N-oxide (CAS 1621681-63-7)
Recommended Standards
- Cefaclor Impurity 60 (CAS CATO-C4X-127060)
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- Lemborexant impurity 1 (CAS 73781-88-1)
- (4-Amino-3-cyano-2-(trifluoromethyl)quinolin-6-yl)boronic acid (CAS 1315335-66-0)
- 4-Chloro-2-(trifluoromethyl)phenylboronic Acid (CAS 313545-41-4)
- 6-Tert-butyl-2-chloropyrimidin-4-amine (CAS 1070217-28-5)
- (4-(2-(4-((Tert-butyldiphenylsilyl)oxy)piperidin-1-yl)ethoxy)-3-chlorophenyl)boronic acid (CAS 1704074-62-3)
- 3-Fluoro-N-methoxy-N-methylbenzamide (CAS 226260-01-1)
- Ethyl 2-((4-methoxyphenyl)amino)-2-oxoacetate (CAS 18522-99-1)
- Proinsulin C-Peptide (55-89) (human) (CAS 11097-48-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com