Proparacaine Impurity 18 2HCl CAS CATO-C4X-202718
| CAS No. | CATO-C4X-202718 |
| Molecular Formula | C13H19ClN2O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Proparacaine Impurity 18 2HCl.
CATO supplies Proparacaine Impurity 18 2HCl (CAS CATO-C4X-202718), a pharmacopoeial impurity reference standard (molecular formula C13H19ClN2O2HCl, MW 307.22 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Proparacaine Impurity 18 2HCl (C13H19ClN2O2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Proparacaine Impurity 18 2HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H19ClN2O2 2*HCl |
| Molecular Weight | 307.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Proparacaine Standards
- Proparacaine Impurity N1 (CAS 100811-81-2)
- Proparacaine Impurity 25 HCl (CAS 1081544-05-9)
- Proparacaine Impurity 20 (CAS 1216179-28-0)
- Proparacaine Impurity 16 (CAS 15788-85-9)
- Proparacaine Impurity 15 (CAS 2102411-30-1)
- Proparacaine Impurity 23 HCl (CAS 2102411-30-1(Free Base))
- Proparacaine Impurity 17 (CAS 2731368-98-0)
- Proparacaine Impurity 5 DiHCl (CAS 2731368-99-1)
Recommended Standards
- Maribavir Impurity 8 (CAS CATO-C4X-30078)
- Dopamine Impurity 117 (CAS CATO-C4X-1908117)
- Piperazine Impurity 1 (CAS 37652-50-9)
- 4-(2-(2-Chloro-3-[2-(1-ethyl-1,4-dihydro-4-quinolinyliden)ethylidene]-1-cyclohexenyl)-1-ethenyl)-1-ethylquinoliniumbromide (CAS 151648-23-6)
- 1,2,2,3,3,4,4,5,5,6,6-undecadeuteriocyclohexanecarbonyl chloride (CAS 2708286-89-7)
- (1-((Methylsulfonyl)methyl)cyclobutyl)methanamine (CAS 1707379-10-9)
- 4-(4-Chlorophenyl)-2-(4-methylphenyl)-4-oxobutanoic acid (CAS 70596-90-6)
- (3S)-Tryptophan EP Impurity I (Mixture of Diastereomers) (CAS 191279-37-5)
- Entecavir Impurity 81 (CAS CATO-C4X-107781)
- [D-His]-Semaglutide B (x TFA Salt) (CAS CATO-C4X-2226117)
Why CATO?
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