Osimertinib Impurity 33 CAS CATO-C4X-204533
| CAS No. | CATO-C4X-204533 |
| Molecular Formula | C56H66N14O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Osimertinib Impurity 33.
As a process- or degradation-related impurity, Osimertinib Impurity 33 (CAS CATO-C4X-204533, C56H66N14O4C2HF3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Osimertinib Impurity 33 (C56H66N14O4C2HF3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Osimertinib Impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C56H66N14O4 2*C2HF3O2 |
| Molecular Weight | 1113.26 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 31.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 14 |
Related Osimertinib Standards
- Osimertinib Impurity 5 (CAS 1009298-59-2)
- Osimertinib Impurity 8 (CAS 1421372-66-8)
- Osimertinib Impurity N1 (CAS 1421372-67-9)
- Osimertinib Impurity N2 (CAS 1421373-36-5 (free base))
- Osimertinib (CAS 1421373-65-0)
- Osimertinib Impurity 10 (CAS 1421373-98-9)
- Osimertinib Impurity N3 (CAS 1421373-99-0)
- Osimertinib-3 (CAS 1446700-26-0)
Recommended Standards
- Cholecalciferol Impurity 28 (CAS CATO-C4X-158628)
- Calcitonin Impurity 24 (CAS CATO-C4X-221824)
- Propofol Impurity 30 (CAS 2215-89-6)
- 4-Amino-3-cyanopicolinic acid (CAS 1807011-38-6)
- (6-Isopropylpyridin-2-yl)methanamine (CAS 1108725-52-5)
- Bis(2-(3H-dinaphtho[2,1-c:1',2'-e]phosphepin-4(5H)-yl)ethyl)amine (CAS 851870-89-8)
- Semaglutide impurity 87 (CAS CATO-C4X-222687)
- N7-benzyl-N4-(3-ethynylphenyl)-6-nitroquinazoline-4,7-diamine (CAS CATO-C3D-262421)
- 2-(4-Chloro-2-methoxyphenyl)ethan-1-ol (CAS 193290-24-3)
- [β-Asp]9-Semaglutide (CAS CATO-CPTD788605)
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