Dacomitinib Impurity 25 CAS CATO-C4X-208625
| CAS No. | CATO-C4X-208625 |
| Molecular Formula | C8H7ClFNO |
| Molecular Weight | 187.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 187.60 g/mol gives Dacomitinib Impurity 25 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Dacomitinib Impurity 25 (CAS CATO-C4X-208625) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7ClFNO and a molecular weight of 187.60 g/mol.
Based on its molecular formula C8H7ClFNO, Dacomitinib Impurity 25 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 187.60 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dacomitinib Impurity 25 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H7ClFNO |
| Molecular Weight | 187.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Dacomitinib Standards
- Dacomitinib Impurity 17 (CAS CATO-C4X-208617)
- Dacomitinib Impurity 18 (CAS CATO-C4X-208618)
- Dacomitinib Impurity 52 (CAS CATO-C4X-208652)
- Dacomitinib Impurity 16 (CAS CATO-C4X-208616)
- Dacomitinib Impurity 23 (CAS CATO-C4X-208623)
- Dacomitinib Impurity 22 (CAS 2250242-14-7)
- Dacomitinib Impurity 15 (CAS CATO-C4X-208615)
- Dacomitinib Impurity 53 (CAS CATO-C4X-208653)
Recommended Standards
- N-(Chloroacetyl)-3-fluoroaniline (CAS 350-81-2)
- 5-Chlorothiazolo[5,4-d]pyrimidin-2(1H)-one (CAS 120209-32-7)
- N-(5-Chloro-2-Fluorophenyl)Acetamide (CAS 398-89-0)
- 7-Chlorothiazolo[5,4-d]pyrimidin-2-ol (CAS 120209-33-8)
- Betamethasone Valerate EP Impurity B (CAS 1879-77-2)
- Tedizolid Impurity 71 (CAS 2295578-89-9)
- Ceritinib Impurity 14 (CAS CATO-C4X-104814)
- 2-(5-Fluoropyridin-2-yl)propan-2-ol (CAS 1195255-81-2)
- (3-Chloro-5-fluoropyridin-2-yl)methanamine (CAS 1211578-98-1)
- N',N'-Dibenzyl-N-(4-tert-butylphenyl)butanediamide (CAS 271775-69-0)
- 1-(4-Chlorobenzyl)pyrrolidin-3-amine dihydrochloride (CAS 169452-11-3)
- 1245816-22-1 3036AD 7-Tributylstannyl[1,2,4]triazolo[1,5-a]pyridine C18H31N3Sn (CAS 1245816-22-1)
- Ethyl 4-(2,6-dichlorobenzyl)-3-methyl-4H-benzo[b][1,4]thiazine-2-carboxylate (CAS 339098-15-6)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com