Dacomitinib Impurity 3 CAS CATO-C4X-20863
| CAS No. | CATO-C4X-20863 |
| Molecular Formula | C24H24Cl2FN5O3S |
| Molecular Weight | 552.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dacomitinib Impurity 3.
Dacomitinib Impurity 3 (CAS CATO-C4X-20863) is a certified pharmaceutical impurity reference standard with the molecular formula C24H24Cl2FN5O3S and a molecular weight of 552.45 g/mol.
Based on its molecular formula C24H24Cl2FN5O3S, Dacomitinib Impurity 3 contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 552.45 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dacomitinib Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H24Cl2FN5O3S |
| Molecular Weight | 552.45 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Dacomitinib Standards
- Dacomitinib Impurity 6 (CAS CATO-C4X-20866)
- Dacomitinib Impurity 21 (CAS CATO-C4X-208621)
- Dacomitinib Impurity 20 (CAS CATO-C4X-208620)
- Dacomitinib Impurity 54 (CAS CATO-C4X-208654)
- Dacomitinib Impurity 42 (CAS CATO-C4X-208642)
- Dacomitinib Impurity 19 (CAS CATO-C4X-208619)
- Dacomitinib Impurity 48 (CAS CATO-C4X-208648)
- Dacomitinib Impurity 37 (CAS CATO-C4X-208637)
Recommended Standards
- Epitheaflagallin 3-O-gallate (CAS 102067-92-5)
- CAY10681 (CAS 1542066-69-2)
- ARQ-621 (CAS 1095253-39-6)
- tert-butyl 3-{bis[(tert-butoxy)carbonyl]amino}-5-(bromomethyl)-6-fluoro-1H-indazole-1-carboxylate (CAS 1037207-03-6)
- Gadoxetate Impurity 14 (CAS 158599-72-5)
- Mirogabalin Impurity 46 Formate Salt (CAS 2165847-73-2 (free base))
- Aprepitant impurity 62 (CAS CATO-C4X-114162)
- n-(4-Aminophenyl)-n-methylethane-1-sulfonamide (CAS 1040070-45-8)
- Taurine Impurity 3 (CAS 63155-80-6)
- 3-Ethyl-3'-methyl-2,2'-bithiophene (CAS 118168-85-7)
- 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone (CAS 171364-81-1)
- 4-(4-Fluorophenoxy)picolinic acid (CAS 1094369-57-9)
- 9-(3-Aminopropyl)-8-((6-iodobenzo-[d][1,3]dioxol-5-yl)thio)-9H-purin-6-amine (CAS 1333155-97-7)
- Semaglutide impurity 36 (CAS CATO-C4X-222636)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com