Bictegravir Impurity 4 HCl CAS CATO-C4X-21814
| CAS No. | CATO-C4X-21814 |
| Molecular Formula | C14H11F5N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Bictegravir Impurity 4 HCl (CAS CATO-C4X-21814, C14H11F5N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Bictegravir Impurity 4 HCl (C14H11F5N2HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bictegravir Impurity 4 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11F5N2 HCl |
| Molecular Weight | 338.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Bictegravir Standards
- Bictegravir Related Compound 2 (CAS 1110772-05-8)
- Bictegravir Impurity 7 (CAS 1284248-73-2)
- Bictegravir Related Compound C001/Dolutegravir Intermediate-1 (CAS 1335210-23-5)
- Bictegravir (CAS 1611493-60-7)
- Bictegravir sodium (CAS 1807988-02-8)
- Bictegravir-15N, d2 (CAS CATO-C4X-21811)
- Bictegravir Impurity 10(2R,5S,13aS) (CAS CATO-C4X-218110)
- Bictegravir impurity 11 (CAS CATO-C4X-218111)
Recommended Standards
- Dapagliflozin Impurity 180 (CAS CATO-C4X-1138180)
- Bumetanide Impurity 5 (CAS 22892-96-2)
- Prilocaine EP Impurity E HCl (CAS 35891-99-7)
- 2-Amino-7-bromo-5-fluoroquinazoline (CAS 1379341-83-9)
- 5-(6-Bromo-2-fluoro-3-methoxyphenyl)oxazole (CAS 2364584-91-6)
- 2-(4-Bromophenyl)-5-chlorobenzo[d]oxazole (CAS 122351-86-4)
- Methyl 4-hydroxyhex-2-ynoate (CAS 112780-04-8)
- 3-Hydroxy-2-(4-methanesulfonyl-2-oxazol-2-yl-benzoyl)-cyclohex-2-enone (CAS 1231580-68-9)
- 2-((5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)thio)-N-(4-methoxyphenyl)acetamide (CAS 262858-64-0)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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