Avatrombopag Impurity 8 CAS CATO-C4X-22348
| CAS No. | CATO-C4X-22348 |
| Molecular Formula | C29H34Cl2N6O3S2 |
| Molecular Weight | 649.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 649.65 g/mol gives Avatrombopag Impurity 8 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Avatrombopag Impurity 8 (CAS CATO-C4X-22348) is a certified pharmaceutical impurity reference standard with the molecular formula C29H34Cl2N6O3S2 and a molecular weight of 649.65 g/mol.
The molecular framework of Avatrombopag Impurity 8 (C29H34Cl2N6O3S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Avatrombopag Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H34Cl2N6O3S2 |
| Molecular Weight | 649.65 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 121 (CAS CATO-C4X-2234121)
- Avatrombopag impurity 136 (CAS CATO-C4X-2234136)
- Avatrombopag (CAS 570406-98-3)
- Avatrombopag Impurity 3 (CAS CATO-C4X-22343)
- Avatrombopag Impurity 58 (CAS CATO-C4X-223458)
- Avatrombopag Impurity 142 (CAS CATO-C4X-2234142)
- Avatrombopag Impurity 100 (CAS CATO-C4X-2234100)
- Avatrombopag Impurity 45 (CAS CATO-C4X-223445)
Recommended Standards
- Bis(2-phenylpyridine-C2,N)-bis(aquo)iridium(III) trifluoromethanesulfonate (CAS 1149344-60-4)
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- Relugolix Impurity 20 (CAS CATO-C4X-242920)
- Bibrocathol - API Standards (CAS 6915-57-7)
- Orphenadrine EP Impurity A (CAS 5472-13-9)
- Leflunomide Impurity 2 (CAS 827029-20-9)
- Fluocinolone Acetonide Impurity 47 (CAS 389119-98-6)
- 5-Hydroxy-3-(trifluoromethyl)picolinamide (CAS 1803855-14-2)
- 2-((4-Butyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(3,4-difluorophenyl)acetamide (CAS 868255-43-0)
- Methyl 5-(bromomethyl)-2-methoxyisonicotinate (CAS 944838-11-3)
- tert-butyl 2-{[(tert-butoxy)carbonyl](piperidin-3-ylmethyl)amino}acetate (CAS 1795361-16-8)
- 1-Methyl-2-(m-tolyloxy)-1H-indole-3-carbaldehyde (CAS 338416-84-5)
- 2'-Deoxy-5-(methylthio)-uridine (CAS 14985-32-1)
- Acetyl Tripeptide-1 (CAS 350595-76-5)
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