Cyclophosphamide Impurity 12 CAS CATO-C4X-230612
| CAS No. | CATO-C4X-230612 |
| Molecular Formula | C8H20ClN2O4P |
| Molecular Weight | 274.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Cyclophosphamide Impurity 12 (CAS CATO-C4X-230612, C8H20ClN2O4P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Cyclophosphamide Impurity 12 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 274.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H20ClN2O4P |
| Molecular Weight | 274.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | -0.5 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cyclophosphamide Standards
- 4-Oxo Cyclophosphamide (CAS 27046-19-1)
- Cyclophosphamide impurity 40 (CAS CATO-C4X-230640)
- Cyclophosphamide Impurity 12 (CAS 78149-83-4)
- Cyclophosphamide Impurity 19 (CAS 22089-17-4)
- Cyclophosphamide Impurity 47 (CAS CATO-C4X-230647)
- Cyclophosphamide impurity 01 (CAS 35144-64-0)
- Cyclophosphamide Impurity 9 (CAS 40277-05-2)
- Cyclophosphamide Impurity 21 (CAS 2517939-95-4)
Recommended Standards
- Methyl 1-(chlorosulfonyl)imidazo[1,5-a]pyridine-6-carboxylate (CAS 2126161-95-1)
- 4-Chloro-3-(difluoromethoxy)-5-(methylthio)thiophene-2-carboxylic acid (CAS 1707727-86-3)
- 6-Chloro-4-(2-fluorophenyl)quinazolin-2(1H)-one (CAS 40069-75-8)
- 5-(2-Amino-4-chloro-5-sulfamoylphenyl)-1H-tetrazole (CAS 82212-14-4)
- Niclosamide Impurity 4 (CAS 16739-21-2)
- Mometasone Furoate EP Impurity D (CAS 83881-09-8)
- Cyanocobalamin Impurity 13 (CAS 17234-76-3)
- 9-Benzyl-3,6-dibromocarbazole (CAS 118599-27-2)
- (S)-tert-Butyl 3-(pyridin-2-yloxy)pyrrolidine-1-carboxylate (CAS 1224514-70-8)
- (R)-tert-Butyl 2-(2-oxoethyl)piperidine-1-carboxylate (CAS 639458-46-1)
- 4-Bromo-2-(fluoromethyl)-6-methylpyridine (CAS 2760431-15-8)
- Ethyl 3-ethyl-6,7-dimethylquinoxaline-2-carboxylate (CAS 2042186-98-9)
- 2-Chloro-1-(difluoromethyl)-3,4-difluorobenzene (CAS 1261561-92-5)
- Fibrinogen-Binding Inhibitor Peptide (CAS 89105-94-2)
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