Alectinib Impurity 91 CAS CATO-C4X-283691
| CAS No. | CATO-C4X-283691 |
| Molecular Formula | C12H15IO2 |
| Molecular Weight | 318.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Alectinib Impurity 91 (CAS CATO-C4X-283691, C12H15IO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Alectinib Impurity 91 (C12H15IO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H15IO2 |
| Molecular Weight | 318.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | I-containing |
Related Alectinib Standards
- Alectinib Impurity 3 (CAS 1256584-73-2)
- Alectinib Impurity 67 (CAS CATO-C4X-283667)
- Alectinib impurity 01 (CAS 1256584-82-3)
- Alectinib impurity 27 (CAS CATO-C4X-283627)
- Alectinib Impurity 58 (CAS CATO-C4X-283658)
- Alectinib Impurity 48 (CAS CATO-C4X-283648)
- Alectinib Impurity 1 (CAS 1256578-99-0)
- Alectinib Impurity 65 (CAS CATO-C4X-283665)
Recommended Standards
- 4,4,5,5-Tetramethyl-2-(3-((2,2,2-trifluoroethyl)thio)phenyl)-1,3,2-dioxaborolane (CAS 1026797-07-8)
- 2-{[(3,5-dichlorophenyl)amino]methylidene}-2,3-dihydro-1H-indene-1,3-dione 78872-37-4 MS-11212 (CAS 78872-37-4)
- 4-Bromo-N-(3-hydroxypropyl)-3,5-dimethoxybenzamide (CAS 1153274-26-0)
- tert-Butyl 4-iodo-3-methyl-benzoate (CAS 360059-33-2)
- Levonorgestrel EP Impurity A (CAS 1260525-53-8)
- Vitamin A Impurity 22 (CAS 56013-05-9)
- Bupivacaine Impurity 29 (CAS 2774312-11-5)
- 7-(Methylamino)naphthalen-2-ol (CAS 377734-57-1)
- 2-(6-(3-Fluorophenyl)-1H-indol-3-yl)acetonitrile (CAS 1214383-76-2)
- 5,10,15,20-tetraphenyl-21<I>H</I>,23<I>H</I>-zinc porphine (CAS 14074-80-7)
- 3-(o-Tolyloxy)isobenzofuran-1(3H)-one (CAS 61133-35-5)
- (2E)-3-(2,4,6-trimethylphenyl)prop-2-enal (CAS 131534-70-8)
- Cefotaxime Impurity 41 (CAS CATO-C4X-121241)
- Semaglutide impurity 289 (CAS CATO-C4X-2226289)
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