Abemaciclib CAS CATO-C4X-2937131
| CAS No. | CATO-C4X-2937131 |
| Molecular Formula | C12H7ClF2N4 |
| Molecular Weight | 280.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Abemaciclib (CAS CATO-C4X-2937131), a pharmacopoeial impurity reference standard (molecular formula C12H7ClF2N4, MW 280.66 g/mol) used for the identification and quantification of trace impurities in APIs.
Abemaciclib (C12H7ClF2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF2N4 |
| Molecular Weight | 280.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib Impurity 151 (CAS CATO-C4X-2937151)
- Abemaciclib Impurity 130 (CAS CATO-C4X-2937130)
- Abemaciclib Impurity 165 (CAS CATO-C4X-2937165)
- Abemaciclib Impurity 174 (CAS CATO-C4X-2937174)
- Abemaciclib Impurity 146 (CAS CATO-C4X-2937146)
- Abemaciclib Impurity 128 (CAS CATO-C4X-2937128)
- Abemaciclib Impurity 5 (CAS CATO-C4X-29375)
- Abemaciclib Impurity 97 (CAS CATO-C4X-293797)
Recommended Standards
- Methyl 1-(3-chlorophenyl)-4-hydroxy-6-oxo-1,6-dihydropyridazine-3-carboxylate (CAS 339029-80-0)
- 3-Chloro-N-(tetrahydro-2-furanylmethyl)-5-(trifluoromethyl)-2-pyridinamine (CAS 1036444-19-5)
- FG-2216 (CAS 223387-75-5)
- 3-Chloro-2-(piperidin-4-yloxy)-5-(trifluoromethyl)pyridine (CAS 1092352-80-1)
- Efinaconazole Impurity 26 (CAS 2055038-63-4)
- Entrectinib Impurity 6 (CAS 1889329-24-1)
- Venetoclax Impurity 124 (CAS CATO-C4X-2495124)
- N-(5-Chloro-6-((2-hydroxyethyl)amino)-3-nitropyrazin-2-yl)acetamide (CAS 87591-65-9)
- Ethyl 2-methylenepentanoate (CAS 3550-06-9)
- 5-Benzyl-1H-imidazol-2-amine hydrochloride (CAS 862254-42-0)
- Crisaborole impurity 110 (CAS CATO-C4X-2021110)
- (1S,4S)-2-methyl-2,5-diazabicyclo[2.2.1]heptane dihydrochloride (CAS 127420-27-3)
- 2-(2-propoxyphenyl)ethanamine (CAS 39515-69-0)
- D-Glu3-Tirzepatide (CAS CATO-CPTD788927)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com