Abemaciclib Impurity 146 CAS CATO-C4X-2937146
| CAS No. | CATO-C4X-2937146 |
| Molecular Formula | C11H12BrClN2 |
| Molecular Weight | 287.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Abemaciclib Impurity 146.
Abemaciclib Impurity 146 (CAS CATO-C4X-2937146) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12BrClN2 and a molecular weight of 287.58 g/mol.
The molecular framework of Abemaciclib Impurity 146 (C11H12BrClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Abemaciclib Impurity 146 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H12BrClN2 |
| Molecular Weight | 287.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity 5 (CAS CATO-C4X-29375)
- Abemaciclib Impurity 97 (CAS CATO-C4X-293797)
- Abemaciclib Impurity 165 (CAS CATO-C4X-2937165)
- Abemaciclib Impurity 130 (CAS CATO-C4X-2937130)
- Abemaciclib Impurity N2 (CAS 1231930-29-2)
- Abemaciclib impurity 106 (CAS CATO-C4X-2937106)
- Abemaciclib Impurity 93 (CAS 2177297-18-4)
- Abemaciclib (CAS CATO-C4X-2937131)
Recommended Standards
- 4-Bromo-2-chloro-N-(1-methylpyrrolidin-2-ylidene)aniline (CAS 27033-86-9)
- N,O-Bis(tert-butyldimethylsilyl)acetamide [tert-Butyldimethylsilylating Agent] (CAS 82112-21-8)
- 3-Bromo-2-tert-Butyl-6-chloroimidazo[1,2-a]pyridine (CAS 904813-68-9)
- 1H-indole-3-sulfonyl chloride, 4,5,6,7-tetrafluoro- (CAS 1092351-43-3)
- Mirabegron Impurity 43 (CAS 1627515-83-6)
- Fosfomycin Impurity 80 (CAS CATO-C4X-131680)
- Flomoxef Impurity 66 (CAS CATO-C4X-138266)
- (2,5-Dimethylphenyl)(pyridin-3-yl)methanone (CAS 42374-46-9)
- [4-(2-Dimethylamino-5-trifluoromethyl-pyridin-3-yl)-phenyl]-carbamic acid ethyl ester (CAS 1311279-43-2)
- Niraparib Impurity 63 (CAS CATO-C4X-232963)
- Furo[3,2-b]pyridin-2-ylmethanol (CAS 162537-61-3)
- N-(4'-sulfamoyl-[1,1'-biphenyl]-4-yl)acetamide (CAS 873411-51-9)
- 7α-Chloro-16α-methyl Prednisolone (CAS 67452-97-5)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com