Abemaciclib Impurity 5 CAS CATO-C4X-29375
| CAS No. | CATO-C4X-29375 |
| Molecular Formula | C15H14F2N4 |
| Molecular Weight | 288.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Abemaciclib Impurity 5 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 288.30 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Abemaciclib Impurity 5 (CAS CATO-C4X-29375, C15H14F2N4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Abemaciclib Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H14F2N4 |
| Molecular Weight | 288.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib Impurity 97 (CAS CATO-C4X-293797)
- Abemaciclib Impurity 146 (CAS CATO-C4X-2937146)
- Abemaciclib Impurity 165 (CAS CATO-C4X-2937165)
- Abemaciclib Impurity N2 (CAS 1231930-29-2)
- Abemaciclib impurity 106 (CAS CATO-C4X-2937106)
- Abemaciclib Impurity 93 (CAS 2177297-18-4)
- Abemaciclib Impurity 130 (CAS CATO-C4X-2937130)
- Abemaciclib (CAS CATO-C4X-2937131)
Recommended Standards
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- Troxipide Impurity 21 (CAS 31638-97-8)
- Cefaclor Impurity 10 (CAS CATO-C4X-127010)
- Suzetrigine Impurity 43 (CAS CATO-C4X-336943)
- Eldecalcitol Impurity 9 (CAS 200636-42-6)
- Tyrphostin AG 1024 (CAS 65678-07-1)
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