Abemaciclib Impurity 93 CAS 2177297-18-4
| CAS No. | 2177297-18-4 |
| Molecular Formula | C11H13BrF2N2 |
| Molecular Weight | 291.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C11H13BrF2N2, Abemaciclib Impurity 93 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 291.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Abemaciclib Impurity 93 (CAS 2177297-18-4), a pharmacopoeial impurity reference standard (molecular formula C11H13BrF2N2, MW 291.14 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H13BrF2N2 |
| Molecular Weight | 291.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity N2 (CAS 1231930-29-2)
- Abemaciclib impurity 106 (CAS CATO-C4X-2937106)
- Abemaciclib Impurity 5 (CAS CATO-C4X-29375)
- Abemaciclib Impurity 97 (CAS CATO-C4X-293797)
- Abemaciclib Impurity 146 (CAS CATO-C4X-2937146)
- Abemaciclib Impurity 165 (CAS CATO-C4X-2937165)
- Abemaciclib Impurity 88 (CAS CATO-C4X-293788)
- Abemaciclib Impurity 130 (CAS CATO-C4X-2937130)
Recommended Standards
- 4-(1-Boc-pyrrolidin-2-yl)benzeneboronic acid (CAS 1027103-15-6)
- Ozenoxacin Impurity 66 (CAS 23612-56-8)
- 1-Ethyl-3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)urea (CAS 1031431-96-5)
- Crisaborole impurity 152 (CAS CATO-C4X-2021152)
- Pyridoxine Impurity 6 (CAS 1385767-85-0)
- Doxapram Impurity 7 (CAS 3471-97-4)
- Palbociclib Impurity 167 (CAS CATO-C4X-1125167)
- 1-(2-Bromo-5-fluorophenyl)butan-2-one (CAS 1247532-04-2)
- 4-(Bicyclo[2.2.1]heptan-2-yl)butan-2-ol (CAS 827299-50-3)
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile (CAS 2058046-22-1)
- 3-(1-fluoropropyl)azetidine (CAS 1785430-06-9)
- (R)-(4-benzylmorpholin-3-yl)methanol hydrochloride (CAS 714971-27-4)
- 1,4-Bis(octadecylamino)anthracene-9,10-dione (CAS 65177-52-8)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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