Abemaciclib Impurity 46 CAS CATO-C4X-293746
| CAS No. | CATO-C4X-293746 |
| Molecular Formula | C39H51ClN12 |
| Molecular Weight | 723.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Abemaciclib Impurity 46.
As a process- or degradation-related impurity, Abemaciclib Impurity 46 (CAS CATO-C4X-293746, C39H51ClN12) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Abemaciclib Impurity 46 (C39H51ClN12) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C39H51ClN12 |
| Molecular Weight | 723.36 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 12 |
Related Abemaciclib Standards
- Abemaciclib Impurity 45 (CAS CATO-C4X-293745)
- Abemaciclib impurity 119 (CAS CATO-C4X-2937119)
- Abemaciclib Impurity 144 (CAS CATO-C4X-2937144)
- Abemaciclib Impurity 58 (CAS CATO-C4X-293758)
- Abemaciclib Impurity 179 (CAS CATO-C4X-2937179)
- Abemaciclib Impurity 90 (CAS CATO-C4X-293790)
- Abemaciclib Impurity 101 (CAS CATO-C4X-2937101)
- Abemaciclib Impurity 172 (CAS CATO-C4X-2937172)
Recommended Standards
- (1S)-3,3mu-Bis[2,4,6-tris(1-methylethyl)phenyl]-1,1mu-binaphthalene-2,2mu-diol 908338-44-3 (CAS 908338-44-3)
- Brostallicin (CAS 203258-60-0)
- (S)-3,3'-Bis(2,4,6-triisopropylphenyl)-[1,1'-binaphthalene]-2,2'-diol 1898AB 247123-09-7 C50H58O2 (CAS 247123-09-7)
- Valrubicin (CAS 56124-62-0)
- Vigabatrin EP Impurity F (CAS 794466-81-2)
- Troxipide Impurity 26 (CAS 2198252-47-8)
- Noscapine impurity N1 (CAS 92621-03-9)
- Cefovecin Impurity 4 (CAS 2916470-18-1)
- 4-(3,4,5-Trimethoxyphenyl)-3-thiosemicarbazide (CAS 206762-46-1)
- Tert-butyl 4-(3-hydroxy-2-phenylpropyl)piperazine-1-carboxylate (CAS 189298-13-3)
- Hydrochlorothiazide Impurity 30 (CAS CATO-C4X-117730)
- Methyl 2-(4-bromonaphthalen-1-yl)acetate (CAS 14311-34-3)
- 4-Methoxypiperidine-4-carbonitrile (CAS 1082040-34-3)
- Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 330456-24-1)
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