Abemaciclib Impurity 49 CAS CATO-C4X-293749
| CAS No. | CATO-C4X-293749 |
| Molecular Formula | C8H2Cl2F2N4 |
| Molecular Weight | 263.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Abemaciclib Impurity 49 (C8H2Cl2F2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Abemaciclib Impurity 49 (CAS CATO-C4X-293749, C8H2Cl2F2N4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Abemaciclib Impurity 49 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H2Cl2F2N4 |
| Molecular Weight | 263.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Abemaciclib Standards
- Abemaciclib Impurity 164 (CAS CATO-C4X-2937164)
- Abemaciclib Impurity 35 (CAS CATO-C4X-293735)
- Abemaciclib Impurity 158 (CAS CATO-C4X-2937158)
- Abemaciclib Impurity 147 (CAS 2189739-28-2)
- Abemaciclib Impurity 185 (CAS 871258-57-0)
- Abemaciclib impurity 109 (CAS CATO-C4X-2937109)
- Abemaciclib Impurity N4 (CAS 1231930-33-8)
- Abemaciclib impurity 110 (CAS CATO-C4X-2937110)
Recommended Standards
- 2-Amino-5-iodonicotinamide (CAS 1629278-26-7)
- 2-amino-5-iodobenzoic acid (CAS 5326-47-6)
- 2-Bromo-5-(difluoromethoxy)-1H-benzo[d]imidazole (CAS 1803895-85-3)
- Methyl 6-iodonicotinate (CAS 173157-33-0)
- Mirogabalin Impurity 179 (CAS CATO-C4X-2924179)
- Quinapril EP Impurity E (CAS 2055735-09-4)
- Brivaracetam Impurity 166 (CAS 2755924-55-9)
- Methyl 6-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (CAS 1342811-51-1)
- PhB-OCH3 (CAS 2416400-58-1)
- N-[3-(hydroxymethyl)phenyl]acetamide (CAS 16375-94-3)
- Ethyl 3-Imidazo[1,5-a]pyridinecarboxylate (CAS 81803-60-3)
- Ethyl 1-methyl-6-(trifluoromethyl)piperidine-3-carboxylate (CAS 1956332-75-4)
- ethyl 4,6-dichloro-5-fluoro-pyridine-3-carboxylate (CAS 154012-17-6)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
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