Abemaciclib Impurity 81 CAS CATO-C4X-293781
| CAS No. | CATO-C4X-293781 |
| Molecular Formula | C28H33F2N7O |
| Molecular Weight | 521.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Abemaciclib Impurity 81.
Abemaciclib Impurity 81 (CAS CATO-C4X-293781) is a certified pharmaceutical impurity reference standard with the molecular formula C28H33F2N7O and a molecular weight of 521.60 g/mol.
Abemaciclib Impurity 81 (C28H33F2N7O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Abemaciclib Impurity 81 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C28H33F2N7O |
| Molecular Weight | 521.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Abemaciclib Standards
- Abemaciclib Impurity 80 (CAS CATO-C4X-293780)
- Abemaciclib Impurity 103 (CAS CATO-C4X-2937103)
- Abemaciclib Impurity 84 (CAS CATO-C4X-293784)
- Abemaciclib Impurity 134 (CAS CATO-C4X-2937134)
- Abemaciclib Impurity 17 (CAS CATO-C4X-293717)
- Abemaciclib Impurity 18 (CAS CATO-C4X-293718)
- Abemaciclib Impurity 25 (CAS CATO-C4X-293725)
- Abemaciclib Impurity 66 (CAS CATO-C4X-293766)
Recommended Standards
- H-Ala-Phe-Lys-AMC (I-1045.0050) (CAS 120928-02-1)
- Nicardipine Impurity 43 (CAS CATO-C4X-171043)
- (R,S)-BisPh-Pybox (CAS 497172-36-8)
- Rosuvastatin Impurity 24 (CAS 894787-93-0)
- Bisoprolol Impurity 27 (CAS 66722-57-4)
- Indapamide EP Impurity B (CAS 63968-75-2)
- Valganciclovir Impurity 33 HCI (CAS 960495-42-5；960582-59-6（free base）)
- (4-Cyano-2-fluorophenyl)methanesulfonyl chloride (CAS 1258640-95-7)
- 2-(2,4-Dimethylphenyl)-1H-pyrazol-3(2H)-one (CAS 1379042-31-5)
- 1,3,5-Pentanetricarboxylic acid, 3-acetyl-, 1,5-bis(1,1-dimethylethyl) 3-ethyl ester (CAS 1135619-58-7)
- Ethyl 2-(2,4-dichlorophenyl)ethanimidate hydrochloride (CAS 5922-21-4)
- 2-Chloro-n-[1-(4-fluorophenyl)-3,3-dimethylbutyl]acetamide (CAS 1311314-70-1)
- N,N'-(1,3,4-Thiadiazole-2,5-diyl)bis(2-methoxyacetamide) (CAS 61785-08-8)
- (Leu31,Pro34)-Peptide YY (human) trifluoroacetate salt (CAS 179986-95-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com