Acalabrutinib Impurity 27 CAS CATO-C4X-305527
| CAS No. | CATO-C4X-305527 |
| Molecular Formula | C5H5Cl2N3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Acalabrutinib Impurity 27 (CAS CATO-C4X-305527) is a certified pharmaceutical impurity reference standard with the molecular formula C5H5Cl2N3HCl and a molecular weight of 214.47 g/mol.
Owing to a nitrile group, chlorine substitution, Acalabrutinib Impurity 27 is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 214.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5Cl2N3 HCl |
| Molecular Weight | 214.47 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Acalabrutinib Standards
- Acalabrutinib (CAS 1420477-60-6)
- Acalabrutinib-D4 (CAS 1420477-60-6(Unlabelled))
- Acalabrutinib Impurity 26 (CAS 1794737-26-0)
- Acalabrutinib Impurity N1 (CAS 1952316-43-6)
- Acalabrutinib Impurity 14 (CAS 2097168-73-3（free base）)
- Acalabrutinib Impurity 24 (CAS 2097352-14-0)
- Acalabrutinib Impurity 4 (CAS 2198380-46-8)
- Acalabrutinib Impurity 16 (CAS 2230757-50-1)
Recommended Standards
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- 1-(pyrrolidin-3-yl)-2,5-dihydro-1H-pyrrole (CAS 1354954-30-5)
- Gly-Neuroendocrine Regulatory Peptide-3 (human, mouse, rat) trifluoroacetate salt (CAS 1815618-19-9)
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