Lotilaner Impurity 22 CAS CATO-C4X-325622
| CAS No. | CATO-C4X-325622 |
| Molecular Formula | C8H8O3S |
| Molecular Weight | 184.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lotilaner Impurity 22.
Lotilaner Impurity 22 (CAS CATO-C4X-325622) is a certified pharmaceutical impurity reference standard with the molecular formula C8H8O3S and a molecular weight of 184.21 g/mol.
Lotilaner Impurity 22 (C8H8O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8O3S |
| Molecular Weight | 184.21 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Sulfur Atoms | 1 |
Related Lotilaner Standards
- Lotilaner Impurity 24 (CAS CATO-C4X-325624)
- Lotilaner Impurity 21 (CAS CATO-C4X-325621)
- Lotilaner Impurity 4 (CAS CATO-C4X-32564)
- Lotilaner Impurity 20 (CAS CATO-C4X-325620)
- Lotilaner Impurity 23 (CAS CATO-C4X-325623)
- Lotilaner Impurity 29 (CAS 2226274-70-8)
- Lotilaner Impurity 7 (CAS CATO-C4X-32567)
- Lotilaner Impurity 15 (CAS CATO-C4X-325615)
Recommended Standards
- Methyl 5-acetylthiophene-2-carboxylate(Arotinolol Impurity 6) (CAS 4101-81-9)
- 2-(Ethylthio)-5-nitropyridine (CAS 107756-05-8)
- Aclidinium bromide Impurity 8 (CAS 4075-58-5)
- 2-Amino-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxylic acid (CAS 1105191-92-1)
- Cefixime Impurity 54 (CAS CATO-C4X-113954)
- Semaglutide impurity 106 (CAS CATO-C4X-2226106)
- Ambroxol impurity 99 (CAS CATO-C4X-108599)
- 2-Bromo-3,6-dimethylpyridine (CAS 38749-92-7)
- (6R)-4-oxo-5-azaspiro[2.4]heptane-6-carboxylic acid (CAS 2166118-43-8)
- N-(6-Ethoxy-3-(2-ethoxyethyl)benzo[d]thiazol-2(3H)-ylidene)cyclopropanecarboxamide (CAS 865174-36-3)
- 2-Amino-6-methyl-5-(prop-2-yn-1-yl)pyrimidin-4-ol (CAS 81887-01-6)
- 4-Fluoro-3-(2-chloro-phenylcarbamoyl)phenylboronic acid (CAS 1451393-31-9)
- Benzyl (S)-2-benzyl-3-oxo-3,4-dihydropyrazine-1(2H)-carboxylate (CAS 500782-67-2)
- Liraglutide Sodium Salt (CAS 204656-20-2（free base）)
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