Tivozanib Impurity 5 CAS CATO-C4X-34005
| CAS No. | CATO-C4X-34005 |
| Molecular Formula | C18H17ClN2O3 |
| Molecular Weight | 344.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tivozanib Impurity 5.
Tivozanib Impurity 5 (CAS CATO-C4X-34005) is a certified pharmaceutical impurity reference standard with the molecular formula C18H17ClN2O3 and a molecular weight of 344.79 g/mol.
Tivozanib Impurity 5 (C18H17ClN2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tivozanib Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H17ClN2O3 |
| Molecular Weight | 344.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tivozanib Standards
- Tivozanib Impurity 29 (CAS CATO-C4X-340029)
- Tivozanib Impurity 3 (CAS CATO-C4X-34003)
- Tivozanib Impurity 2 (CAS CATO-C4X-34002)
- Tivozanib Impurity 7 (CAS CATO-C4X-34007)
- Tivozanib Impurity 24 (CAS CATO-C4X-340024)
- Tivozanib Impurity 28 (CAS CATO-C4X-340028)
- Tivozanib Impurity 17 (CAS CATO-C4X-340017)
- Tivozanib Impurity 4 (CAS CATO-C4X-34004)
Recommended Standards
- Tolvaptan Impurity 70 (CAS CATO-C4X-195570)
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- N-(tert-butyl)-7-chloro-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 343375-46-2)
- Ethyl 4-{[(4-chlorophenyl)methyl]amino}-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (CAS 1221715-35-0)
- Troxipide Impurity 12 (CAS CATO-C4X-214812)
- Ixazomib Impurity 75 (CAS CATO-C4X-126775)
- Tenofovir disoproxil Impurity 92 (CAS 16606-55-6)
- 1-[2-(1H-pyrazol-1-yl)phenyl]ethan-1-one (CAS 25699-96-1)
- 4-(Benzyloxy)-3-(5,5-dimethyl-1,3-dioxan-2-yl)-5-fluorobenzoic acid (CAS 2766130-42-9)
- 5-Amino-6-bromo-4-chloropyridazin-3(2H)-one (CAS 2447686-30-6)
- 6-((3-Nitrobenzyl)thio)pyridazin-3-amine (CAS 121041-55-2)
- tert-Butyl (S)-2-((S)-1,2-dihydroxyethyl)morpholine-4-carboxylate (CAS 2137073-66-4)
- Ethyl 2-(4-nitrophenyl)ethanimidate hydrochloride (CAS 75584-64-4)
- Semaglutide Impurity 150 xTFA (CAS CATO-C4X-2226150)
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