Resmetirom impurity 133 CAS 1314924-95-2
| CAS No. | 1314924-95-2 |
| Molecular Formula | C7H9ClN2 |
| Molecular Weight | 156.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Resmetirom impurity 133 (CAS 1314924-95-2) is a certified pharmaceutical impurity reference standard with the molecular formula C7H9ClN2 and a molecular weight of 156.61 g/mol.
Structurally, Resmetirom impurity 133 (C7H9ClN2) contains a nitrile group, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 156.61 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Resmetirom impurity 133 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H9ClN2 |
| Molecular Weight | 156.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Resmetirom Standards
- Resmetirom impurity 135 (CAS 3096249-74-7)
- Resmetirom Impurity 3 (CAS 6629-04-5)
- Resmetirom Impurity 44 (CAS CATO-C4X-291244)
- Resmetirom Impurity 1 (CAS 141-30-0)
- Resmetirom impurity 64 (CAS 2375196-15-7)
- Resmetirom impurity 65 (CAS 1696366-11-6)
- Resmetirom impurity 134 (CAS 28165-63-1)
- Resmetirom Impurity 4 (CAS 107228-51-3)
Recommended Standards
- Telmisartan Impurity 23 (CAS 84859-27-8)
- Entecavir Impurity 45 (CAS 3587-60-8)
- Acetamiprid metabolite IM-1-4 (CAS 120739-62-0)
- Chloroxylenol (CAS 1321-23-9)
- Verteporfin Impurity 1 (CAS CATO-C4X-35491)
- Apixaban Impurity 68 (CAS CATO-C4X-108868)
- Relugolix Impurity 81 (CAS CATO-C4X-242981)
- 3-(4-Bromophenyl)-5-methyl-4-phenylisoxazole (CAS 181697-19-8)
- 4,4,5,5-Tetramethyl-2-(2,4,6-triisopropylphenyl)-1,3,2-dioxaborolane (CAS 914675-53-9)
- 3-((4-Bromophenyl)sulfonyl)-2-(furan-2-yl)thiazolidine (CAS 667910-29-4)
- Citalopram (CAS 59729-33-8)
- 1-(4-Chlorophenyl)-2-phenoxyethan-1-amine (CAS 1492202-64-8)
- 【禁售不询】PIPERONYL METHYL KETONE (CAS 4676-39-5)
- Insulin Glargine (CAS 160337-95-1)
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