Sorafenib Impurity 34 CAS 121-50-6
| CAS No. | 121-50-6 |
| Molecular Formula | C7H5ClF3N |
| Molecular Weight | 195.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Sorafenib Impurity 34 (CAS 121-50-6) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5ClF3N and a molecular weight of 195.57 g/mol.
The molecular framework of Sorafenib Impurity 34 (C7H5ClF3N) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF3N |
| Molecular Weight | 195.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib Impurity 31 (CAS 62476-58-8)
- Sorafenib EP Impurity C (CAS 320-51-4)
- Sorafenib Impurity 49 (CAS 1446410-29-2)
- Sorafenib Impurity 37 (CAS CATO-C4X-112437)
- Sorafenib Impurity 20 (CAS 329-01-1)
- Sorafenib Impurity 54 (CAS 67455-41-8)
- Sorafenib Impurity 46 (CAS 53750-66-6)
- Sorafenib Impurity 57 (CAS 99970-10-2)
Recommended Standards
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- 2-Chloro-6-fluoroimidazo[1,2-a]pyridine-3-carbonitrile (CAS 1428521-72-5)
- Dalilesen impurity 56 (CAS CATO-C4X-301056)
- Cefodizime Impurity 5 (CAS 120533-30-4)
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- B-[2-[(2,2-Dimethyl-1-oxopropyl)amino]-3-pyridinyl]boronic acid (CAS 1036243-43-2)
- 3,3-Bis(4-(dimethylamino)phenyl)isobenzofuran-1(3H)-one (CAS 5339-80-0)
- 1-[(4S)-4-Phenyl-2-thioxo-3-thiazolidinyl]ethanone (CAS 1519060-84-4)
- 6-Bromo-2-methyl-3(2H)-pyridazinone (CAS 1123169-25-4)
- 2-Methyl-4-oxo-4H-pyran-3-yl acetate (CAS 28787-36-2)
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- PACAP-Related Peptide (PRP), rat (CAS 132769-35-8)
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