Sorafenib Impurity 49 CAS 1446410-29-2
| CAS No. | 1446410-29-2 |
| Molecular Formula | C8H10ClN3O |
| Molecular Weight | 199.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sorafenib Impurity 49 (C8H10ClN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Sorafenib Impurity 49 (CAS 1446410-29-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H10ClN3O and a molecular weight of 199.64 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Sorafenib Impurity 49 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H10ClN3O |
| Molecular Weight | 199.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Sorafenib Standards
- Sorafenib Impurity 37 (CAS CATO-C4X-112437)
- Sorafenib Impurity 31 (CAS 62476-58-8)
- Sorafenib Impurity 34 (CAS 121-50-6)
- Sorafenib EP Impurity C (CAS 320-51-4)
- Sorafenib Impurity 20 (CAS 329-01-1)
- Sorafenib Impurity 57 (CAS 99970-10-2)
- Sorafenib Impurity 32 (CAS 50528-86-4)
- Sorafenib Impurity 54 (CAS 67455-41-8)
Recommended Standards
- 2-(2-chloroanilino)acetohydrazide 2-[(2-chlorophenyl)amino]acetohydrazide (non-preferred name) 2371-29-1 (CAS 2371-29-1)
- Opicapone lmpurity 18 (CAS CATO-C4X-240418)
- N'-(6-chloropyridin-2-yl)propionohydrazide (CAS 66999-52-8)
- Opicapone Impurity 75 (CAS >95%)
- Diacerein Impurity 8 (CAS 6030-60-0)
- Rosuvastatin Impurity 216 (CAS 65372-09-0)
- Vericiguat Impurity 61 (CAS CATO-C4X-289661)
- (E)-1-bromo-5-methylhex-3-ene (CAS 134287-57-3)
- sodium metavanadate (CAS 13718-26-8)
- Venetoclax Impurity 51 (CAS CATO-C4X-249551)
- 4-Oxo-4,5,6,7-tetrahydrofuro[3,2-c]pyridine-2-carboxylic acid (CAS 1557547-88-2)
- 3-(1-Ethyl-5-methyl-1H-pyrazol-4-yl)propiolic acid (CAS 1354705-04-6)
- 4H-1,2,4-oxadiazol-5-one (CAS 36193-60-9)
- Glu17-Semaglutide (CAS CATO-C4X-2226209)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com