Sorafenib Impurity 31 CAS 62476-58-8
| CAS No. | 62476-58-8 |
| Molecular Formula | C7H5ClF3N |
| Molecular Weight | 195.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrile group, fluorine/chlorine substitution, an aromatic ring system, Sorafenib Impurity 31 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 195.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Sorafenib Impurity 31 (CAS 62476-58-8), a pharmacopoeial impurity reference standard (molecular formula C7H5ClF3N, MW 195.57 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF3N |
| Molecular Weight | 195.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib Impurity 34 (CAS 121-50-6)
- Sorafenib EP Impurity C (CAS 320-51-4)
- Sorafenib Impurity 49 (CAS 1446410-29-2)
- Sorafenib Impurity 37 (CAS CATO-C4X-112437)
- Sorafenib Impurity 20 (CAS 329-01-1)
- Sorafenib Impurity 54 (CAS 67455-41-8)
- Sorafenib Impurity 46 (CAS 53750-66-6)
- Sorafenib Impurity 57 (CAS 99970-10-2)
Recommended Standards
- 5-Chloro-2-(trifluoromethyl)aniline (CAS 445-14-7)
- 5-(Chloromethyl)-2-(trifluoromethyl)pyridine (CAS 386715-33-9)
- 4-Chloro-5-methyl-2-(trifluoromethyl)pyridine (CAS 220870-80-4)
- 4-Amino-3-chlorobenzotrifluoride (CAS 39885-50-2)
- Clarithromycin Impurity 23 (CAS 470-12-2)
- Naproxen Impurity 34 (CAS CATO-C4X-170834)
- Cyproheptadine impurity 12 (CAS 31232-24-3)
- 18:0 dimethylacetal (CAS 14620-55-4)
- Ketotifen (CAS 34580-13-7)
- Methyl 3-(acetylthio)bicyclo[1.1.1]Pentane-1-carboxylate (CAS 131543-52-7)
- L-(+)-Gulonic Acid gamma-Lactone (CAS 1128-23-0)
- 3-(2-Chlorophenyl)-cyclohexanol (CAS 1341419-32-6)
- 4-Amino-2-methyl-1H-imidazole-5-carbothioamide (CAS 108513-29-7)
- Glucagon-like peptide 2 (CAS 89750-15-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com