Aprepitant impurity 66 CAS CATO-C4X-114166
| CAS No. | CATO-C4X-114166 |
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 534.43 g/mol gives Aprepitant impurity 66 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Aprepitant impurity 66 (CAS CATO-C4X-114166), a pharmacopoeial impurity reference standard (molecular formula C23H21F7N4O3, MW 534.43 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Aprepitant impurity 66 (C23H21F7N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 534.43 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Aprepitant impurity 66 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant Impurity 3 (CAS 172822-28-5)
- Aprepitant Impurity 4 (CAS 172822-29-6)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 6 (CAS 170902-81-5)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
Recommended Standards
- Aprepitant Impurity 9 (CAS CATO-C4X-11419)
- Fmoc-Gln-OPfp (CAS 86061-00-9)
- 9,9'-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(9H-carbazole) (CAS 1082549-89-0)
- Diquinoxalino[2,3-a:2',3'-c]phenazine-2,3,8,9,14,15-hexacarbonitrile (CAS 887401-68-5)
- Milbemycin Oxime EP Impurity A (CAS 51596-11-3)
- Iobitridol Impurity 20 (CAS CATO-C4X-317820)
- Paclitaxel Impurity 33 (CAS 92950-42-0)
- 1-((4-Aminophenyl)amino)-4,8-dihydroxy-5-nitroanthracene-9,10-dione (CAS 89455-26-5)
- 1-(1-Cyclopropylethyl)piperazine (CAS 1018646-28-0)
- 2-Fluoro-3-(hydroxymethyl)phenol (CAS 960001-66-5)
- 3-Cyano-N-(4-(3-(trifluoromethyl)phenoxy)but-2-yn-1-yl)benzamide (CAS 1421513-23-6)
- 2-(4-(2-Methoxyethyl)-4H-1,2,4-triazol-3-yl)piperidine dihydrochloride (CAS 1361116-52-0)
- 2,4-Dichloro-6-isopropylthieno[3,2-d]pyrimidine (CAS 1780595-68-7)
- Calcium-Like Peptide 3 (CAS 261969-05-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com