Aprepitant Impurity 6 CAS 170902-81-5
| CAS No. | 170902-81-5 |
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Aprepitant Impurity 6 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Aprepitant Impurity 6 (CAS 170902-81-5, C23H21F7N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Aprepitant Impurity 6 (C23H21F7N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 534.43 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant Impurity 3 (CAS 172822-28-5)
- Aprepitant Impurity 4 (CAS 172822-29-6)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant impurity 66 (CAS CATO-C4X-114166)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
Recommended Standards
- Aprepitant Impurity 9 (CAS CATO-C4X-11419)
- Fmoc-Gln-OPfp (CAS 86061-00-9)
- 9,9'-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(9H-carbazole) (CAS 1082549-89-0)
- Diquinoxalino[2,3-a:2',3'-c]phenazine-2,3,8,9,14,15-hexacarbonitrile (CAS 887401-68-5)
- Relugolix Impurity 165 (CAS CATO-C4X-2429165)
- Lenvatinib Impurity 107 (CAS CATO-C4X-1140107)
- Cariprazine Impurity 60 (CAS CATO-C4X-240860)
- Iron Oxide Pigment Black (CAS 120899-48-1)
- Dibenzo[b,i]phenazine (CAS 258-76-4)
- 3-Chloro-6-[(2,4-dichlorophenyl)methyl]pyridazine (CAS 338779-03-6)
- Glycyrrhizic Acid Impurity 40 (CAS CATO-C4X-253740)
- Ethyl 7-oxo-7-[3-(piperidinomethyl)phenyl]heptanoate (CAS 898793-83-4)
- Ibrutinib Impurity 189 (CAS CATO-C4X-1064189)
- Semaglutide impurity 75 (CAS CATO-C4X-222675)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com