Dexamethasone Sodium Phosphate EP Impurity B Disodium Salt CAS 151-73-5
| CAS No. | 151-73-5 |
| Molecular Formula | C22H28FO8P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Dexamethasone Sodium Phosphate EP Impurity B Disodium Salt (CAS 151-73-5, C22H28FO8PNa) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dexamethasone Sodium Phosphate EP Impurity B Disodium Salt (C22H28FO8PNa) contains a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H28FO8P 2*Na |
| Molecular Weight | 493.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone EP Impurity H (CAS 10106-41-9)
- Dexamethasone Impurity 116 (CAS 107419-73-8)
- Dexamethasone EP Impurity G (CAS 1177-87-3)
- Dexamethasone impurity 63 (CAS 1202001-99-7)
- Dexamethasone impurity 65 (CAS 1202002-01-4)
- Dexamethasone EP Impurity E (CAS 13209-41-1)
- Dexamethasone Impurity 112 (CAS 134429-26-8)
- Dexamethasone impurity 90 (CAS 134429-31-5)
Recommended Standards
- Sitagliptin Impurity 174 HCl (CAS 486459-88-5（free base）)
- Delafloxacin Impurity 16 (CAS CATO-C4X-263716)
- LCZ-696 Impurity 31 (CAS CATO-C4X-169631)
- (2-Cyclobutylpyridin-3-yl)methanamine hydrochloride (CAS 2490709-10-7)
- 1-(1,3-Dimethyl-1H-pyrazol-4-yl)-N-((5-fluoro-1,3-dimethyl-1H-pyrazol-4-yl)methyl)methanamine hydrochloride (CAS 1856035-45-4)
- 2-Methoxy-6-(1-phenyl-ethylideneaminooxymethyl)-benzoic acid methyl ester (CAS 1171923-23-1)
- N-(3-methylpentan-2-yl)cyclohexanamine (CAS 1042613-79-5)
- 4-(2-Bromoethyl)-2-chloro-1-fluorobenzene (CAS 1260809-91-3)
- Linagliptin impurity 149 (CAS CATO-C4X-1101149)
- Semaglutide impurity 289 (CAS CATO-C4X-2226289)
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