Fluocortolone Pivalate EP Impurity A CAS 152-97-6
| CAS No. | 152-97-6 |
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Fluocortolone Pivalate EP Impurity A (C22H29FO4) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Fluocortolone Pivalate EP Impurity A (CAS 152-97-6, C22H29FO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Fluocortolone Pivalate EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluocortolone Standards
- Fluocortolone Acetate (CAS 1176-82-5)
- Fluocortolone Impurity 8 (CAS CATO-C4X-22308)
- Fluocortolone Impurity 6 (CAS 36130-02-6)
- Fluocortolone Impurity 9 (CAS CATO-C4X-22309)
- Fluocortolone Pivalate (CAS 29205-06-9)
- Fluocortolone Pivalate EP Impurity D (CAS CATO-C4X-223014)
- Fluocortolone Hexanoate (CAS 303-40-2)
- Fluocortolone Impurity 10 (CAS CATO-C4X-223010)
Recommended Standards
- Fluorometholone D Homo Derivative (CAS CATO-C4X-19339)
- Fluorometholone (CAS 426-13-1)
- 6-beta-Methyl Fluorometholone (CAS 3918-13-6)
- Hydroxy Pioglitazone-d4 (M-IV) (CAS 1188263-49-1)
- Arotinolol Impurity 17 (CAS CATO-C4X-185417)
- Relugolix Impurity 210 (CAS CATO-C4X-2429210)
- Norfloxacin Impurity C25 (CAS 74011-47-5)
- 2-(2-Cyano-6-(difluoromethyl)-4-methylpyridin-3-yl)acetic acid (CAS 1805023-24-8)
- (S)-2-Chloro-8-methyl-7,8-dihydro-5H-pyrano[4,3-b]pyridin-5-one (CAS 2673370-66-4)
- (9-Cyclohexyl-9H-purin-6-yl)-benzylamine (CAS 42240-63-1)
- 3-Nitro-1H-pyrrolo[2,3-c]pyridine-4-carboxylic acid (CAS 1190320-32-1)
- α-Chloro Imazamox (CAS 1797116-63-2)
- 4-Isopropylbenzotrifluoride (CAS 32445-99-1)
- Tirzepatide Impurity 38 (CAS CATO-C4X-324038)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com