Aprepitant impurity 02 CAS 1523569-90-5
| CAS No. | 1523569-90-5 |
| Molecular Formula | C23H22F7N4O6P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Aprepitant impurity 02.
As a process- or degradation-related impurity, Aprepitant impurity 02 (CAS 1523569-90-5, C23H22F7N4O6PC7H17NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C23H22F7N4O6PC7H17NO5, Aprepitant impurity 02 contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 809.63 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aprepitant impurity 02 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H22F7N4O6P 2*C7H17NO5 |
| Molecular Weight | 809.63 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Erlotinib Impurity 48 (CAS 2055840-54-3)
- Dopamine impurity 120 (CAS 3490-09-3)
- Salbutamol Glyoxal Impurity (CAS CATO-C4X-1176167)
- Ethyl 5-Bromoindole-2-carboxylate (CAS 16732-70-0)
- 3-[(4-Methoxyphenyl)methyl]azetidine hydrochloride (CAS 937612-77-6)
- (6-Bromoquinolin-8-yl)methanol (CAS 1266728-35-1)
- 4-(Bromomethyl)-1-phenylpyrazole (CAS 153863-63-9)
- (S)-2-Oxooxazolidine-4-carboxylic acid (CAS 19525-95-2)
- Methyl 2-hydroxy-2,3-dihydro-1H-pyrrolizine-6-carboxylate (CAS 2388474-74-4)
- Tirzepatide Impurity 50 (CAS CATO-C4X-324050)
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