Efavirenz Impurity 2 CAS 154801-74-8
| CAS No. | 154801-74-8 |
| Molecular Formula | C14H9ClF3NO2 |
| Molecular Weight | 315.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Efavirenz Impurity 2 (CAS 154801-74-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H9ClF3NO2 and a molecular weight of 315.67 g/mol.
The molecular framework of Efavirenz Impurity 2 (C14H9ClF3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H9ClF3NO2 |
| Molecular Weight | 315.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz (CAS 154598-52-4)
- Efavirenz Impurity 10 (CAS 2125704-30-3)
- Efavirenz Impurity 24 (CAS CATO-C4X-162724)
- Efavirenz Impurity 25 (CAS CATO-C4X-162725)
- Efavirenz Impurity 28 (CAS CATO-C4X-162728)
- Efavirenz Racemate (CAS 177530-93-7)
- Efavirenz 2-Desoxo-2-methly (CAS 1258498-53-1)
- Efavirenz USP Related Compound B (CAS 440124-96-9)
Recommended Standards
- Sorafenib Impurity 4 (CAS 871555-75-8)
- N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-hydroxybenzamide (CAS 5683-92-1)
- N-(4-chlorophenyl)-2,2-difluoro-2-(4-fluorophenoxy)acetamide (CAS 338792-33-9)
- 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]benzohydrazide (CAS 1092343-30-0)
- Nintedanib Impurity 3 (CAS 2093243-16-2)
- Isavuconazole Impurity 182 (CAS CATO-C4X-1236182)
- Chlorpheniramine Impurity 11（ Maleate Salt） (CAS 23052-94-0)
- 2-(2,6-Dichlorophenyl)acetyl chloride (CAS 61875-53-4)
- 1-(3,4-Dichlorophenyl)cyclobutanecarboxylic Acid (CAS 84485-58-5)
- 1-(4-Hydroxyphenyl)piperidin-4-ol (CAS 866109-91-3)
- Amorolfine impurity 68 (CAS CATO-C4X-154268)
- (R)-7a-Allyl-2,3,7,7a-tetrahydro-1H-indene-1,5(6H)-dione (CAS 161773-56-4)
- Bortezomib Impurity 13 (CAS 1446194-56-4)
- Serpent Peptide 2AcOH (CAS 823202-99-9(free base))
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