Efavirenz USP Related Compound B CAS 440124-96-9
| CAS No. | 440124-96-9 |
| Molecular Formula | C14H11ClF3NO2 |
| Molecular Weight | 317.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies Efavirenz USP Related Compound B (CAS 440124-96-9), a certified reference material (molecular formula C14H11ClF3NO2, MW 317.69 g/mol) for analytical method development and quality control.
Efavirenz USP Related Compound B (C14H11ClF3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11ClF3NO2 |
| Molecular Weight | 317.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz Impurity 3 (CAS 205755-86-8)
- Efavirenz Impurity 6 (CAS 1627575-36-3)
- Efavirenz 2-Desoxo-2-methly (CAS 1258498-53-1)
- rac Efavirenz-d4 (CAS 1246812-58-7)
- Efavirenz (CAS 154598-52-4)
- Efavirenz Impurity 10 (CAS 2125704-30-3)
- Efavirenz Impurity 2 (CAS 154801-74-8)
- Efavirenz Impurity 24 (CAS CATO-C4X-162724)
Recommended Standards
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