Erlotinib Impurity 122 CAS 1709-44-0
| CAS No. | 1709-44-0 |
| Molecular Formula | C7H7NO |
| Molecular Weight | 121.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Erlotinib Impurity 122 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Erlotinib Impurity 122 (CAS 1709-44-0) is a certified pharmaceutical impurity reference standard with the molecular formula C7H7NO and a molecular weight of 121.14 g/mol.
The molecular framework of Erlotinib Impurity 122 (C7H7NO) is characterized by an amide group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C7H7NO |
| Molecular Weight | 121.14 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Erlotinib Standards
- Erlotinib Impurity 113 (CAS 587-02-0)
- Erlotinib Impurity 116 (CAS 15411-43-5)
- Erlotinib Impurity 114 (CAS 14235-81-5)
- Erlotinib Impurity 115 (CAS 52670-38-9)
- Erlotinib Impurity 120 (CAS 54060-30-9)
- Erlotinib Impurity 24 (CAS 134690-40-7)
- Erlotinib Impurity 112 (CAS 99-03-6)
- Erlotinib Impurity 117 (CAS 139-85-5)
Recommended Standards
- 1,3-Dihydrofuro[3,4-c]pyridine (CAS 126230-90-8)
- 3-(1h-Pyrazol-4-yl)propanenitrile (CAS 1296225-28-9)
- 3-(1H-pyrazol-4-yl)prop-2-yn-1-amine (CAS 1248812-37-4)
- 4-Methyl-4H-furo[3,2-b]pyrrole (CAS 132120-22-0)
- Tadalafil Impurity 21 (CAS 951661-85-1)
- Paliperidone Impurity 129 (CAS 46020-63-7)
- Cefcapene Impurity 90 Disodium Salt (CAS 28242-91-3 (free acid))
- 5-(2-Amino-4,6-dihydroxypyrimidin-5-yl)-2-hydroxypentanoic acid (CAS 79333-39-4)
- (2-(((2-Formylphenyl)amino)methyl)phenyl)boronic acid (CAS 2527827-01-4)
- 1-Bromo-3-chloro-5-(2-methoxyethoxy)benzene (CAS 1345471-20-6)
- 4-(2,6-Difluorobenzoyl)-1-[(4-methoxyphenyl)methyl]-3-methyl-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 317833-54-8)
- Ethyl 4-(4-acetamidophenoxy)-2-(methylsulfanyl)pyrimidine-5-carboxylate (CAS 383148-62-7)
- N,N-Dibutyl-7-nitro-4-benzofurazanamine (CAS 74400-49-0)
- Peptide Impurity 24 (CAS CATO-CPTD788824)
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