Canagliflozin Impurity 27 CAS 898566-17-1
| CAS No. | 898566-17-1 |
| Molecular Formula | C18H14FIS |
| Molecular Weight | 408.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Canagliflozin Impurity 27 (CAS 898566-17-1, C18H14FIS) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Canagliflozin Impurity 27 (C18H14FIS) contains sulfur-containing functionality, fluorine/iodine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H14FIS |
| Molecular Weight | 408.27 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/I-containing |
| Sulfur Atoms | 1 |
Related Canagliflozin Standards
- Canagliflozin Impurity 20 (CAS CATO-C4X-112320)
- Canagliflozin Impurity 51 (CAS 2444540-10-5)
- Canagliflozin Impurity 52 (CAS CATO-C4X-112352)
- Canagliflozin Impurity 53 (CAS CATO-C4X-112353)
- Canagliflozin Impurity 54 (CAS CATO-C4X-112354)
- Canagliflozin Impurity 55 (CAS CATO-C4X-112355)
- Canagliflozin Impurity 76 (CAS 2952941-15-8)
- Canagliflozin Impurity 77 (CAS CATO-C4X-112377)
Recommended Standards
- 2-((2,4-Dichlorobenzyl)amino)-1,1-bis(4-fluorophenyl)ethanol (CAS 338771-37-2)
- (5-Bromofuran-2-yl)(3-(5-(thiophen-3-yl)-1,3,4-oxadiazol-2-yl)piperidin-1-yl)methanone (CAS 1797174-09-4)
- (5-Bromofuran-2-yl)(4-(5-(furan-2-yl)-1,3,4-thiadiazol-2-yl)piperidin-1-yl)methanone (CAS 1351587-01-3)
- 2-(2-(4-Bromo-2-fluorophenyl)-4-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-1H-imidazol-1-yl)ethanol (CAS 1282516-77-1)
- Atrasentan Impurity 208 (CAS CATO-C4X-3347208)
- Rimegepant Impurity 43 (CAS CATO-C4X-248743)
- Fosfomycin Impurity 25 (CAS CATO-C4X-131625)
- Ampicillin Impurity 37 (CAS CATO-C4X-144337)
- (R)-4-Chloro-6-(pyrrolidin-3-yloxy)pyrimidine hydrochloride (CAS 1261234-80-3)
- tert-Butyl ((1R,3S,5S)-9-benzyl-9-azabicyclo[3.3.1]nonan-3-yl)carbamate (CAS 153431-10-8)
- 4-((4-Chlorophenyl)thio)-[1,2,4]triazolo[4,3-a]quinoxaline (CAS 245039-48-9)
- 3-Methyl-N-{2-[({5-oxo-2H,3H,5H-[1,3]thiazolo[2,3-b]quinazolin-3-yl}methyl)sulfanyl]phenyl}benzamide (CAS 477868-85-2)
- Methyl 2-ethyl-1H-imidazole-4-carboxylate (CAS 52039-58-4)
- Semaglutide impurity 259 (CAS CATO-C4X-2226259)
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