Aprepitant Impurity 27 CAS 183901-47-5
| CAS No. | 183901-47-5 |
| Molecular Formula | C27H24F7NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Aprepitant Impurity 27.
CATO supplies Aprepitant Impurity 27 (CAS 183901-47-5), a pharmacopoeial impurity reference standard (molecular formula C27H24F7NO2HCl, MW 563.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Aprepitant Impurity 27 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 563.94 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Aprepitant Impurity 27 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H24F7NO2 HCl |
| Molecular Weight | 563.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Isavuconazole Impurity 161 (CAS CATO-C4X-1236161)
- Larotrectinib Impurity 20 (CAS CATO-C4X-238020)
- Epinephrine /Adrenaline Impurity 127 (CAS CATO-C4X-1849127)
- 2-(Chloromethyl)-6-(difluoromethyl)-4-methyl-3-nitropyridine (CAS 1805623-90-8)
- O-Benzyl S-(4,6-dimethylpyrimidin-2-yl) carbonothioate (CAS 42116-21-2)
- Palbociclib Impurity 73 (CAS 571188-82-4)
- 3-(2,5-Dimethyl-7-oxo-3,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)- propanoic acid (CAS 883550-13-8)
- 2-Methyl-3-morpholin-4-ylpropanoic acid hydrochloride (CAS 1052522-32-3)
- 2-(Triphenylsilyl)dibenzofuran (CAS 18919-21-6)
- Cholecystokinin, CCK Tetrapeptide (30-33) (CAS 35144-91-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com