Fluocinolone Acetonide Impurity N3 CAS 72498-89-6
| CAS No. | 72498-89-6 |
| Molecular Formula | C25H29FO7 |
| Molecular Weight | 460.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 460.49 g/mol gives Fluocinolone Acetonide Impurity N3 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Fluocinolone Acetonide Impurity N3 (CAS 72498-89-6) is a certified pharmaceutical impurity reference standard with the molecular formula C25H29FO7 and a molecular weight of 460.49 g/mol.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution, Fluocinolone Acetonide Impurity N3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 460.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H29FO7 |
| Molecular Weight | 460.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F-containing |
Related Fluocinolone Standards
- Fluocinolone Acetonide Impurity 33 (CAS CATO-C4X-238133)
- Fluocinolone Acetonide Impurity 45 (CAS 39987-51-4)
- Fluocinolone Acetonide Impurity 44 (CAS 54605-01-5)
- Fluocinolone Acetonide-13C3 (CAS 1262192-25-5)
- Fluocinolone Acetonide EP Impurity A (CAS 106931-78-6)
- Fluocinolone Acetonide Impurity 31 (CAS 1178-54-7)
- Fluocinolone Acetonide Impurity 3 (CAS 4306-83-6)
- Fluocinolone Acetonide Impurity 40 (CAS CATO-C4X-238140)
Recommended Standards
- (E)-N-(4-(2-(benzo[d]thiazol-2-yl)vinyl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (CAS 478049-99-9)
- NDI-034858 (CAS 2272904-53-5)
- Fmoc-Orn(pyrazinylcarbonyl)-OH (CAS 201046-61-9)
- Ceftazidime Impurity 20 (CAS CATO-C4X-121220)
- Ropinirole Impurity 26 (CAS CATO-C4X-174526)
- Etofenamate EP Impurity G (CAS 32508-98-8)
- Allisartan Isoproxil Impurity 21 (CAS CATO-C4X-321721)
- Ytterbium(III) trifluoromethanesulfonate hydrate (CAS 314041-23-1)
- 3-fluorocyclopentan-1-ol (CAS 1504358-95-5)
- 3-Bromomethcathinone Hydrochloride (CAS 676487-42-6)
- 3-Ethylpyrazolo[1,5-a]pyrimidin-6-amine (CAS 1707713-94-7)
- (S)-3-(trimethylsilyl)pyrrolidin-2-one (CAS 406497-08-3)
- N-(4-chlorophenyl)succinamic acid (CAS 17722-52-0)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
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