Metoprolol Impurity 20 CAS 18995-35-2
| CAS No. | 18995-35-2 |
| Molecular Formula | C10H13ClO |
| Molecular Weight | 184.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 184.66 g/mol gives Metoprolol Impurity 20 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Metoprolol Impurity 20 (CAS 18995-35-2) is a certified pharmaceutical impurity reference standard with the molecular formula C10H13ClO and a molecular weight of 184.66 g/mol.
Based on its molecular formula C10H13ClO, Metoprolol Impurity 20 contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 184.66 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13ClO |
| Molecular Weight | 184.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
Related Metoprolol Standards
- Metoprolol Impurity 26 (CAS 69628-98-4)
- Metoprolol Impurity 17 (CAS 158553-31-2)
- Metoprolol Impurity 22 (CAS 123195-72-2)
- Metoprolol Impurity 9 (CAS 1155083-53-6)
- Metoprolol Impurity 18 (CAS 56718-70-8)
- Metoprolol Impurity 29 (CAS 89507-60-8)
- Metoprolol Impurity 21 (CAS 84697-14-3)
- Metoprolol EP Impurity F (CAS 7695-63-8)
Recommended Standards
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- Dapoxetine Impurity 53 (CAS 22422-27-1)
- 2651-46-9 Benzene, (4-chlorobutoxy)- 4-Chlorobutyl phenyl ether AI3-17426 EINECS 220-174-3 (CAS 2651-46-9)
- Dopamine Impurity 92 (CAS 344791-89-5)
- Fluticasone Impurity 54 (CAS 4571-51-1)
- Aprocitentan Impurity 6 (CAS CATO-C4X-33556)
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- Ethyl 2-amino-4-(4-chloro-3-methylphenyl)thiophene-3-carboxylate (CAS 899684-01-6)
- 3-(7-Bromo-3-oxo-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)benzonitrile (CAS 1396808-72-2)
- 4-Iodo-1,2,5-trimethyl-1H-pyrrole-3-carbaldehyde (CAS 1432311-25-5)
- 2-Bromoisobutyrophenone (CAS 188777-50-6)
- 2,5-Diphenylpyrimidine (CAS 29134-16-5)
- 2-(2-Benzoyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetic acid (CAS 930395-95-2)
- Cholecystokinin Octapeptide (sulfated) (H-2060.0005) (CAS 25679-23-6)
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