Sorafenib Impurity 17 CAS 2004659-83-8
| CAS No. | 2004659-83-8 |
| Molecular Formula | C20H19N5O3 |
| Molecular Weight | 377.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 377.40 g/mol gives Sorafenib Impurity 17 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Sorafenib Impurity 17 (CAS 2004659-83-8) is a certified pharmaceutical impurity reference standard with the molecular formula C20H19N5O3 and a molecular weight of 377.40 g/mol.
Sorafenib Impurity 17 (C20H19N5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sorafenib Impurity 17 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H19N5O3 |
| Molecular Weight | 377.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 5 |
Related Sorafenib Standards
- Sorafenib Impurity 62 (CAS CATO-C4X-112462)
- Sorafenib Impurity 35 (CAS CATO-C4X-112435)
- Sorafenib Impurity 41 (CAS 1129683-83-5)
- Sorafenib EP Impurity D (CAS 2206827-14-5)
- Sorafenib Impurity 13 (CAS CATO-C4X-112413)
- Sorafenib EP Impurity F (CAS 1285533-84-7)
- Sorafenib Impurity 4 (CAS 871555-75-8)
- Sorafenib Impurity 2(PAPE-ethyl carbamate) (CAS 2206827-12-3)
Recommended Standards
- Apixaban Impurity 12 (CAS 1423803-24-0)
- tert-Butyl 15-bromopentadecanoate (CAS 905302-64-9)
- 3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (CAS 1129669-05-1)
- N-Ethyl-1-(furan-2-ylmethyl)-2-imino-8-methyl-5-oxo-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide (CAS 510760-71-1)
- Paroxetine Impurity 25 (CAS CATO-C4X-103525)
- Pregabalin Impurity 124 (CAS CATO-C4X-1312124)
- Melphalan EP Impurity G (CAS 2238824-43-4)
- 3-methanesulfonyl-4-methoxyaniline (CAS 13736-78-2)
- 4-Fluoro-1-naphthaldehyde (CAS 172033-73-7)
- 2,6-Bis(trifluoromethyl)phenylboronic Acid (CAS 681812-07-7)
- Dipotassium (2-nitro-1-sulfanidylethenyl)sulfanide (CAS 25963-52-4)
- Difelikefalin Impurity 15 (CAS 368866-07-3)
- 1-(2-pyrimidinyl)-2-piperidinone 1-pyrimidin-2-ylpiperidin-2-one 116247-92-8 A803578 (CAS 116247-92-8)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
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