Efavirenz Related Compound A CAS 209414-27-7
| CAS No. | 209414-27-7 |
| Molecular Formula | C13H11ClF3NO |
| Molecular Weight | 289.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Efavirenz Related Compound A is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Efavirenz Related Compound A (CAS 209414-27-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H11ClF3NO and a molecular weight of 289.68 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Efavirenz Related Compound A is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 289.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Efavirenz Related Compound A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11ClF3NO |
| Molecular Weight | 289.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2016 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Efavirenz Standards
- Efavirenz Aminoalcohol (CAS 154598-58-0)
- Efavirenz Impurity 13 (CAS 927812-33-7)
- Efavirenz USP Related Compound A (CAS 209414-27-7；154598-58-0)
- Efavirenz USP Related Compound C (CAS 391860-73-4)
- Efavirenz (CAS 154598-52-4)
- Efavirenz Impurity 10 (CAS 2125704-30-3)
- Efavirenz Impurity 2 (CAS 154801-74-8)
- Efavirenz Impurity 24 (CAS CATO-C4X-162724)
Recommended Standards
- ethyl 2-chloro-3,3,3-trifluoro-2-[(3-methylbutanoyl)amino]propanoate (CAS 329182-55-0)
- 6-Chloro-9-(4-nitrobenzyl)-9H-purine (CAS 4230-26-6)
- 6-Chloro-9-(3-nitrobenzyl)-9H-purine (CAS 6952-15-4)
- 1-Ethyl-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-sulfonyl chloride (CAS 1225726-09-9)
- Vilanterol Impurity 2 (CAS CATO-C4X-19352)
- Enzalutamide Impurity 52 (CAS CATO-C4X-101652)
- Cariprazine Impurity 70 (CAS CATO-C4X-240870)
- 2-((1-(2-Methylallyl)-1H-indol-3-yl)thio)acetonitrile (CAS 61021-47-4)
- N-(2,3-dichlorophenyl)-6-methyl-2-phenylquinoline-4-carboxamide (CAS 337502-85-9)
- 4-Nitro-2-(1H-pyrazol-3-yl)-1H-indole (CAS 827317-33-9)
- Disperse Orange 13 (CAS 6253-10-7)
- Methyl (S)-2-Aminopent-4-Enoate (CAS CATO-C3D-262602)
- Lurbinectedin Impurity 17 (CAS 2248127-63-9)
- Semaglutide impurity 275 (CAS CATO-C4X-2226275)
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