Abemaciclib Impurity N1 CAS 2177297-46-8
| CAS No. | 2177297-46-8 |
| Molecular Formula | C15H21BrN2O |
| Molecular Weight | 325.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Abemaciclib Impurity N1 (CAS 2177297-46-8, C15H21BrN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H21BrN2O, Abemaciclib Impurity N1 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 325.24 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H21BrN2O |
| Molecular Weight | 325.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Abemaciclib Standards
- Abemaciclib Impurity N3 (CAS 1231930-42-9)
- Abemaciclib Impurity 4 (CAS CATO-C4X-29374)
- Abemaciclib Impurity 63 (CAS CATO-C4X-293763)
- Abemaciclib Impurity N7 (CAS 1231930-37-2)
- Abemaciclib Impurity 140 (CAS 2124229-65-6)
- Abemaciclib Impurity 123 (CAS CATO-C4X-2937123)
- Abemaciclib Impurity 154 (CAS CATO-C4X-2937154)
- Abemaciclib Impurity 77 (CAS CATO-C4X-293777)
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- 179175-15-6 3-[4-(Methylsulfonyl)phenyl]-4-phenyl-2,5-furandione 5-Keto Vioxx (CAS 179175-15-6)
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