Apremilast Impurity 1 CAS 608141-44-2
| CAS No. | 608141-44-2 |
| Molecular Formula | C22H24N2O7S |
| Molecular Weight | 460.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Apremilast Impurity 1 is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Apremilast Impurity 1 (CAS 608141-44-2), a pharmacopoeial impurity reference standard (molecular formula C22H24N2O7S, MW 460.50 g/mol) used for the identification and quantification of trace impurities in APIs.
Apremilast Impurity 1 (C22H24N2O7S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Apremilast Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O7S |
| Molecular Weight | 460.50 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Apremilast Standards
Recommended Standards
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- Loratadine EP Impurity D (CAS 100643-71-8)
- Semaglutide Impurity 146 (CAS 2645421-68-5)
- Ataluren Impurity 2 (CAS CATO-C4X-30062)
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- 3-(4-(Pyridin-2-yl)piperazin-1-yl)propanoic acid (CAS 104373-85-5)
- 2-(tert-Butyl)-1-butyl-4-phenyl-5,6-dihydrobenzo[h]quinolin-1-ium tetrafluoroborate (CAS 73286-97-2)
- 5-Amino-6-bromo-N-((1-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)methyl)chromane-8-carboxamide (CAS 947373-34-4)
- 4-(4-Chlorophenyl)-5-[1-(piperidin-1-yl)ethyl]-4h-1,2,4-triazole-3-thiol (CAS 750599-44-1)
- (R)-1-Boc-4-oxopiperidine-2-carboxylic acid ethyl ester 357154-16-6 Ethyl (R)-1-Boc-4-oxopiperidine-2-carboxylate (CAS 357154-16-6)
- Glucagon (19-29) (human, rat, porcine) (CAS 64790-15-4)
Why CATO?
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