Ponatinib Impurity 15 (E-Isomer) CAS CATO-C4X-226915
| CAS No. | CATO-C4X-226915 |
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ponatinib Impurity 15 (E-Isomer) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Ponatinib Impurity 15 (E-Isomer) (CAS CATO-C4X-226915, C29H27F3N6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ponatinib Impurity 15 (E-Isomer) (C29H27F3N6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Ponatinib Standards
- Ponatinib (CAS 943319-70-8)
- Ponatinib Impurity 18 (Z-Isomer) (CAS CATO-C4X-226918)
- Ponatinib Impurity 43 (E-Isomer) (CAS CATO-C4X-226943)
- Ponatinib Impurity 44 (Z-Isomer) (CAS CATO-C4X-226944)
- Ponatinib-d8 (CAS 1562993-37-6)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Ponatinib Active Metabolite AP24567(M42) (CAS 943319-87-7)
- Ponatinib Impurity 54 (CAS CATO-C4X-226954)
Recommended Standards
- Pioglitazone N-beta-D-Glucuronide (Mixture of Diastereomers) (CAS 1296832-75-1)
- GZD824 (CAS 1257628-77-5)
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- Cyclo(-Ala-Arg-Gly-Asp-3-aminomethylbenzoyl) (CAS 153381-95-4)
- Indometacin Impurity 16 (CAS CATO-C4X-147016)
- Lifitegrast Impurity 150 (CAS CATO-C4X-2409150)
- Salbutamol Impurity 217 (CAS CATO-C4X-1176217)
- 4-Chloro-6-isopropoxyquinoline (CAS 1153083-63-6)
- 5-chloro-2-{[(6-methylpyridin-2-yl)methyl]amino}benzoic acid (CAS 1283531-62-3)
- 3-Hydrazinyl-5-methyl-4H-1,2,4-triazol-4-amine hydrochloride (CAS 873-28-9)
- 2-Cyclobutylpyrimidine-5-carbaldehyde (CAS 1517117-22-4)
- 1-(1H-Indol-3-yl)-3-(3-methoxyphenyl)urea (CAS 941879-15-8)
- alpha-Pinene (CAS 2437-95-8)
- Palmitoyl Tripeptide-5 TFA (CAS 623172-55-4（free base）)
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