Ponatinib Impurity 43 (E-Isomer) CAS CATO-C4X-226943
| CAS No. | CATO-C4X-226943 |
| Molecular Formula | C30H28F3N5O |
| Molecular Weight | 531.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ponatinib Impurity 43 (E-Isomer) (C30H28F3N5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Ponatinib Impurity 43 (E-Isomer) (CAS CATO-C4X-226943), a pharmacopoeial impurity reference standard (molecular formula C30H28F3N5O, MW 531.57 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H28F3N5O |
| Molecular Weight | 531.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Ponatinib Standards
- Ponatinib Impurity 44 (Z-Isomer) (CAS CATO-C4X-226944)
- Ponatinib (CAS 943319-70-8)
- Ponatinib Impurity 15 (E-Isomer) (CAS CATO-C4X-226915)
- Ponatinib Impurity 18 (Z-Isomer) (CAS CATO-C4X-226918)
- Ponatinib-d8 (CAS 1562993-37-6)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Ponatinib Active Metabolite AP24567(M42) (CAS 943319-87-7)
- Ponatinib Impurity 54 (CAS CATO-C4X-226954)
Recommended Standards
- Rosuvastatin Impurity 144 (CAS CATO-C4X-1169144)
- Acalabrutinib Impurity 21 (CAS 2412166-56-2)
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- Pyrrolobenzodiazepine Impurity 1 (CAS 204322-85-0)
- Ropinirole Hydrochloride EP Impurity D (CAS 173990-76-6)
- Iobitridol Impurity 36 (CAS CATO-C4X-317836)
- Ursodeoxycholic Acid Impurity 70 (CAS CATO-C4X-142270)
- 2-(1-((4-Methoxyphenyl)sulfonyl)pyrrolidin-2-yl)benzo[d]thiazole (CAS 551930-96-2)
- 4-(2-Chloroacetyl)-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 436088-67-4)
- 2-(Ethoxycarbonyl)-5-fluoro-2,3-dihydro-1H-indene-2-carboxylic acid (CAS 1951439-78-3)
- 4,7-Dibromo-5,6-dimethyl-1H-benzo[d]imidazole (CAS 1613316-63-4)
- N-[2-(2-Chlorophenoxy)ethyl]-3-methoxy-1-propanamine (CAS 1040680-82-7)
- Candesartan Cilexetil Impurity 35 (CAS 1867269-67-7)
- Tirzepatide Impurity 45 (CAS CATO-C4X-324045)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com