Ponatinib Impurity 18 (Z-Isomer) CAS CATO-C4X-226918
| CAS No. | CATO-C4X-226918 |
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 532.56 g/mol gives Ponatinib Impurity 18 (Z-Isomer) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ponatinib Impurity 18 (Z-Isomer) (CAS CATO-C4X-226918, C29H27F3N6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ponatinib Impurity 18 (Z-Isomer) (C29H27F3N6O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Ponatinib Standards
- Ponatinib (CAS 943319-70-8)
- Ponatinib Impurity 15 (E-Isomer) (CAS CATO-C4X-226915)
- Ponatinib Impurity 43 (E-Isomer) (CAS CATO-C4X-226943)
- Ponatinib Impurity 44 (Z-Isomer) (CAS CATO-C4X-226944)
- Ponatinib-d8 (CAS 1562993-37-6)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Ponatinib Active Metabolite AP24567(M42) (CAS 943319-87-7)
- Ponatinib Impurity 54 (CAS CATO-C4X-226954)
Recommended Standards
- GZD824 (CAS 1257628-77-5)
- Cyclo(-Ala-Arg-Gly-Asp-3-aminomethylbenzoyl) (CAS 153381-95-4)
- Pioglitazone N-beta-D-Glucuronide (Mixture of Diastereomers) (CAS 1296832-75-1)
- GSK1838705A (CAS 1116235-97-2)
- Voriconazole Impurity 77 (CAS CATO-C4X-136677)
- Ibuprofen Impurity 34 (CAS CATO-C4X-1082134)
- Carbocisteine Impurity 20 HCl (CAS CATO-C4X-201020)
- 5-(3-Isobutyl-1-methyl-1h-1,2,4-triazol-5-yl)thiophen-2-amine (CAS 1343853-04-2)
- (S)-2-Amino-3-(benzo[d][1,3]dioxol-4-yl)propanoic acid (CAS 1269980-63-3)
- (Chloromethyl)methyldiphenylsilane (CAS 18407-40-4)
- 5-Bromo-2-(cyclopropylmethoxy)aniline (CAS 1019590-24-9)
- N-(2-(Cyclohex-1-en-1-yl)ethyl)-5-((4-fluorobenzyl)oxy)-4-oxo-4H-pyran-2-carboxamide (CAS 1021134-68-8)
- 4-((11-Hydroxyundecyl)oxy)benzaldehyde (CAS 124389-14-6)
- (Met(O)2?)-Glucagon (1-29) (human, rat, porcine) (CAS 75217-63-9)
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