Alprazolam EP Impurity A CAS 27537-87-7
| CAS No. | 27537-87-7 |
| Molecular Formula | C15H14ClN3O |
| Molecular Weight | 287.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Alprazolam EP Impurity A (C15H14ClN3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 287.74 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Alprazolam EP Impurity A (CAS 27537-87-7) is a certified pharmaceutical impurity reference standard with the molecular formula C15H14ClN3O and a molecular weight of 287.74 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14ClN3O |
| Molecular Weight | 287.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Alprazolam Standards
- Alprazolam Impurity 15 (CAS 963-39-3)
- Alprazolam Impurity 7 (CAS 1346606-48-1)
- Alprazolam EP Impurity C (CAS 36916-19-5)
- Alprazolam Impurity 4 (CAS 27610-14-6)
- Alprazolam Impurity 5 (CAS 5220-83-7)
- Alprazolam Impurity 2 (CAS 4016-85-7)
- Alprazolam impurity 24 (CAS CATO-C4X-146024)
- Alprazolam impurity 25 (CAS CATO-C4X-146025)
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