Alprazolam Impurity 15 CAS 963-39-3
| CAS No. | 963-39-3 |
| Molecular Formula | C15H11ClN2O2 |
| Molecular Weight | 286.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Alprazolam Impurity 15.
CATO supplies Alprazolam Impurity 15 (CAS 963-39-3), a pharmacopoeial impurity reference standard (molecular formula C15H11ClN2O2, MW 286.71 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Alprazolam Impurity 15 (C15H11ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 286.71 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H11ClN2O2 |
| Molecular Weight | 286.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Alprazolam Standards
- Alprazolam EP Impurity A (CAS 27537-87-7)
- Alprazolam Impurity 7 (CAS 1346606-48-1)
- Alprazolam EP Impurity C (CAS 36916-19-5)
- Alprazolam Impurity 4 (CAS 27610-14-6)
- Alprazolam Impurity 5 (CAS 5220-83-7)
- Alprazolam Impurity 2 (CAS 4016-85-7)
- Alprazolam impurity 24 (CAS CATO-C4X-146024)
- Alprazolam impurity 25 (CAS CATO-C4X-146025)
Recommended Standards
- Hydrochlorothiazide Impurity 52 (CAS CATO-C4X-117752)
- Clobazam EP Impurity A (CAS 22316-55-8)
- Hydrochlorothiazide impurity 44 (CAS CATO-C4X-117744)
- Oxazepam impurity 16 (CAS CATO-C4X-309016)
- Linaclotide impurity 35 (CAS 1207977-38-5)
- Entecavir Impurity 76 (Racemic mixture) (CAS CATO-C4X-107776)
- Testosterone EP Impurity G (CAS 897-06-3)
- N'-[(1E)-1-(1,3-Dioxo-2,3-dihydro-1H-inden-2-yl)ethylidene]-2-(naphthalen-1-yloxy)acetohydrazide (CAS 1024723-38-3)
- 1-Methyl-N-(4-methylbenzyl)pyrrolidin-3-amine (CAS 1250891-31-6)
- (R)-2-(((Benzyloxy)carbonyl)amino)-3-(2,5-difluorophenyl)propanoic acid (CAS 923563-53-5)
- 2-Bromo-4-chloro-1-(chloromethyl)benzene (CAS 66192-23-2)
- Tetrahydro-2-furanylmethyl 4-hydroxybenzoate (CAS 4470-04-6)
- 3-[(4-Bromophenoxy)methyl]piperidine hydrochloride (CAS 1185304-03-3)
- Tirzepatide Impurity 61 (CAS CATO-C4X-324061)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com