Resmetirom impurity 135 CAS 3096249-74-7
| CAS No. | 3096249-74-7 |
| Molecular Formula | C7H9ClN2 |
| Molecular Weight | 156.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Resmetirom impurity 135 (CAS 3096249-74-7, C7H9ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrile group, chlorine substitution, an aromatic ring system, Resmetirom impurity 135 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 156.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Resmetirom impurity 135 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H9ClN2 |
| Molecular Weight | 156.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Resmetirom Standards
- Resmetirom impurity 133 (CAS 1314924-95-2)
- Resmetirom Impurity 3 (CAS 6629-04-5)
- Resmetirom Impurity 44 (CAS CATO-C4X-291244)
- Resmetirom Impurity 1 (CAS 141-30-0)
- Resmetirom impurity 64 (CAS 2375196-15-7)
- Resmetirom impurity 65 (CAS 1696366-11-6)
- Resmetirom impurity 134 (CAS 28165-63-1)
- Resmetirom Impurity 4 (CAS 107228-51-3)
Recommended Standards
- Acetamiprid metabolite IM-1-4 (CAS 120739-62-0)
- Telmisartan Impurity 23 (CAS 84859-27-8)
- 4-Chloro-2,6-Dimethylphenol (CAS 1123-63-3)
- Entecavir Impurity 45 (CAS 3587-60-8)
- Vildagliptin Impurity 17 (CAS CATO-C4X-110017)
- Ulipristal Impurity 14 (CAS CATO-C4X-191514)
- Rosuvastatin Impurity 92 (CAS CATO-C4X-116992)
- 148492-11-9 4-[2-(4-Fluoro-phenyl)-ethyl]-piperidine 4-[2-(4-fluorophenyl)ethyl]piperidine (CAS 148492-11-9)
- 3-chloro-1H-indazole-6-carbonitrile (CAS 1243389-39-0)
- 1-Methyl-6-oxo-N-(2-(thiophen-3-yl)benzyl)-1,6-dihydropyridazine-3-carboxamide (CAS 1797637-97-8)
- Flomoxef Impurity 10 (CAS CATO-C4X-138210)
- 24240-04-8 beta-Allocryptopine Benzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl- 5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one gamma-Homochelidonine Fagarine I (CAS 24240-04-8)
- N1-(3-Methoxybenzyl)-N2-(2-methoxyethyl)oxalamide (CAS 920347-71-3)
- Liraglutide (CAS 204656-20-2)
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