Verapamil Impurity 25 CAS 3893-01-4
| CAS No. | 3893-01-4 |
| Molecular Formula | C9H11ClO2 |
| Molecular Weight | 186.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 186.64 g/mol gives Verapamil Impurity 25 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Verapamil Impurity 25 (CAS 3893-01-4) is a certified pharmaceutical impurity reference standard with the molecular formula C9H11ClO2 and a molecular weight of 186.64 g/mol.
Structurally, Verapamil Impurity 25 (C9H11ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 186.64 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Verapamil Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H11ClO2 |
| Molecular Weight | 186.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Verapamil Standards
- Verapamil Impurity 27 (CAS 7306-46-9)
- Verapamil EP Impurity B (CAS 3490-06-0)
- Verapamil Impurity 24 (CAS 18086-24-3)
- Verapamil Hydrochloride EP Impurity E (CAS 93-03-8)
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil EP Impurity L (CAS 14046-55-0)
- Verapamil EP Impurity C (CAS 3490-05-9)
- Verapamil Impurity N2 (CAS 3017-96-7)
Recommended Standards
- Losartan EP Impurity D (CAS 83857-96-9)
- Tocopherol impurity 38 (CAS 2011-58-7)
- Nintedanib Impurity 39 (CAS 3395-81-1)
- 2-(Chloromethyl)-1,4-dimethoxybenzene (CAS 3840-27-5)
- Methotrexate EP Impurity H HBr (CAS 67022-39-3(free base))
- Teprenone Impurity 13 (CAS CATO-C4X-208113)
- Propranolol Impurity 6 (CAS 20133-93-1)
- Apixaban Impurity 41 (CAS 536760-29-9)
- 2-Chloro-4-methoxy-5-methylpyridine (CAS 1122090-84-9)
- 1-(2-Bromoethoxy)-3,5-dichlorobenzene (CAS 18800-31-2)
- 3-(Cyclohexylamino)-2,2-dimethylpropanoic acid (CAS 946686-26-6)
- 2-Chloro-N-ethyl-N-(3-nitrobenzyl)acetamide (CAS 1353977-17-9)
- 2-(5-Bromo-2-((3-chlorobenzyl)oxy)phenyl)-1H-benzo[d]imidazole (CAS 62871-41-4)
- FMRF-Like Peptide from snail Helix aspersa (CAS 98495-35-3)
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