Verapamil Impurity 27 CAS 7306-46-9
| CAS No. | 7306-46-9 |
| Molecular Formula | C9H11ClO2 |
| Molecular Weight | 186.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Verapamil Impurity 27 (CAS 7306-46-9), a pharmacopoeial impurity reference standard (molecular formula C9H11ClO2, MW 186.64 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Verapamil Impurity 27 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 186.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11ClO2 |
| Molecular Weight | 186.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
Related Verapamil Standards
- Verapamil Impurity 25 (CAS 3893-01-4)
- Verapamil EP Impurity B (CAS 3490-06-0)
- Verapamil Impurity 24 (CAS 18086-24-3)
- Verapamil Hydrochloride EP Impurity E (CAS 93-03-8)
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil EP Impurity L (CAS 14046-55-0)
- Verapamil EP Impurity C (CAS 3490-05-9)
- Verapamil Impurity N2 (CAS 3017-96-7)
Recommended Standards
- Nintedanib Impurity 39 (CAS 3395-81-1)
- Losartan EP Impurity D (CAS 83857-96-9)
- Nintedanib Impurity 44 (CAS 3395-80-0)
- Tocopherol impurity 38 (CAS 2011-58-7)
- Phenytoin Impurity 23 (CAS 14704-09-7)
- Aztreonam Impurity 45 (CAS CATO-C4X-152245)
- Etrasimod impurity 21 (CAS CATO-C4X-321421)
- 5-Amino-2-chlorobenzaldehyde (CAS 6361-19-9)
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- (2Z)-2,3-Dichloro-N-(6-methoxypyridin-3-yl)-3-[(4-methylphenyl)methanesulfinyl]prop-2-enamide (CAS 1164542-94-2)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com