Azathioprine EP Impurity A CAS 4531-54-8
| CAS No. | 4531-54-8 |
| Molecular Formula | C4H6N4O2 |
| Molecular Weight | 142.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Azathioprine EP Impurity A (CAS 4531-54-8), a pharmacopoeial impurity reference standard (molecular formula C4H6N4O2, MW 142.12 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C4H6N4O2, Azathioprine EP Impurity A contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 142.12 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Azathioprine EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H6N4O2 |
| Molecular Weight | 142.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 4 |
Related Azathioprine Standards
- Azathioprine Impurity N4 (CAS 5167-18-0)
- Azathioprine Impurity 12 (CAS 1192-53-6)
- Azathioprine Impurity 21 (CAS 30467-02-8)
- Azathioprine EP Impurity B (CAS 157930-13-7)
- Azathioprine EP Impurity B (CAS 50-44-2)
- Azathioprine Impurity 9 (CAS 1190008-04-8)
- Azathioprine EP Impurity D (CAS 6339-54-4)
- Azathioprine EP Impurity C (CAS 4897-25-0)
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